Phenotypes associated with this allele

• Allele Symbol: Crkl^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5904959
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crkl^tm1d(EUCOMM)Hmgu/Crkl^tm1d(EUCOMM)Hmgu	involves: 129S4/SvJae * C57BL/6J * C57BL/6N * FVB/N	MGI:7660799

Genotype
MGI:7660799

hm1

• Allelic Composition: Crkl^{tm1d(EUCOMM)Hmgu}/Crkl^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

curly tail ( J:348704 )

• in the UCSD cohort of mice, 26.67% of fetuses exhibit curly tail when mothers are fed a normal 3 ppm folic acid diet

• in the Baylor cohort of mice, 1.9% of fetuses exhibit curly tail alone and 3.8% of fetuses exhibit curly tail with meningomyelocele when mothers are fed a 4 ppm folic acid diet

• no embryos show curly tail on a low-maternal folic acid diet

nervous system

meningomyelocele ( J:348704 )

• in the Baylor cohort of mice, 3.8% of fetuses exhibit curly tail with meningomyelocele when mothers are fed a 4 ppm folic acid diet

exencephaly ( J:348704 )

• in the UCSD cohort of mice, 1.5% of fetuses on a normal folic acid (2 ppm) diet show exencephaly

• in the UCSD cohort of mice, 37.5% of fetuses on a low-maternal folic acid (O.2 ppm) diet show exencephaly

• in the Baylor cohort of mice, 1.9% of embryos exhibit exencephaly when mothers are fed a 4 ppm folic acid diet

embryo

meningomyelocele ( J:348704 )

• in the Baylor cohort of mice, 3.8% of fetuses exhibit curly tail with meningomyelocele when mothers are fed a 4 ppm folic acid diet

skeleton

meningomyelocele ( J:348704 )

• in the Baylor cohort of mice, 3.8% of fetuses exhibit curly tail with meningomyelocele when mothers are fed a 4 ppm folic acid diet