Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Pln*)#Egk
• Allele Name: transgene insertion, Evangelia G Kranias
• Allele ID: MGI:5905137
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Pln*)#Egk/0	Not Specified	MGI:5905138

Genotype
MGI:5905138

tg1

• Allelic Composition: Tg(Myh6-Pln*)#Egk/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:105976 )

• mice die between 2 and 16 weeks of age

postnatal lethality ( J:105976 )

• mice die between 2 and 16 weeks of age

cardiovascular system

abnormal cardiac muscle tissue morphology ( J:105976 )

• myocyte disarray

enlarged heart ( J:105976 )

• 6 week old mice show an increase in heart size

dilated heart ventricle ( J:105976 )

cardiac interstitial fibrosis ( J:105976 )

• massive interstitial fibrosis

dilated cardiomyopathy ( J:105976 )

decreased calcium uptake by cardiac muscle ( J:105976 )

• sarcoplasmic reticulum calcium uptake in hearts is reduced

muscle

abnormal cardiac muscle tissue morphology ( J:105976 )

• myocyte disarray

dilated cardiomyopathy ( J:105976 )

growth/size/body

enlarged heart ( J:105976 )

• 6 week old mice show an increase in heart size

cellular

cardiac interstitial fibrosis ( J:105976 )

• massive interstitial fibrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1P		DOID:0110439	OMIM:609909	J:105976