Phenotypes associated with this allele

• Allele Symbol: Taco1^m1Anu
• Allele Name: ENU mutation 1, Australian National University
• Allele ID: MGI:5905291
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Taco1^m1Anu/Taco1^m1Anu	C57BL/6-Taco1^m1Anu	MGI:5905337

Genotype
MGI:5905337

hm1

• Allelic Composition: Taco1^m1Anu/Taco1^m1Anu
• Genetic Background: C57BL/6-Taco1^m1Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

Purkinje cell degeneration ( J:239883 )

• in the folia of the cerebellum of adult mice

increased astrocyte number ( J:239883 )

• in the optic nerve in adult mice

increased astrocyte size ( J:239883 )

• enlarged in the optic nerve in adult mice

optic nerve atrophy ( J:239883 )

• mild loss of the relatively large myelinated axons in adult mice

vision/eye

optic nerve atrophy ( J:239883 )

• mild loss of the relatively large myelinated axons in adult mice

thin retina inner nuclear layer ( J:239883 )

• in adult mice

thin retina outer plexiform layer ( J:239883 )

• in adult mice

abnormal vision ( J:239883 )

• deficiency in visuomotor behaviour of adult mice with less tracking and fewer head tracks during optokinetic drum experiments

cardiovascular system

thick interventricular septum ( J:239883 )

• in diastole and systole in adult mice

cardiac hypertrophy ( J:239883 )

thick ventricular wall ( J:239883 )

• increased fractional shortening, increased thickening of the left ventricular posterior wall in diastole and systole in adult mice

behavior/neurological

impaired coordination ( J:239883 )

• in the rotarod test, adult mice are unable to improve and have motor learning deficits after 4 days of testing in the hanging wire test, adult mice moved across the wire to reach the box located at the end of it less often and travelled less distance across the wire

abnormal gait ( J:239883 )

• in adult mice

integument

grizzled coat color ( J:239883 )

• premature graying in adult mice

ruffled hair ( J:239883 )

• in adult mice

pigmentation

grizzled coat color ( J:239883 )

• premature graying in adult mice

cellular

abnormal respiratory electron transport chain ( J:239883 )

• decreased abundance of complex IV only

mortality/aging

premature aging ( J:239883 )

• of the skin indicated by premature graying of the coat in adult mice

growth/size/body

cardiac hypertrophy ( J:239883 )