About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Primpolem1Nki
endonuclease-mediated mutation 1, The Netherlands Cancer Institute
MGI:5905761
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Primpolem1Nki/Primpolem1Nki C57BL/6-Primpolem1Nki MGI:5905775


Genotype
MGI:5905775
hm1
Allelic
Composition		 Primpolem1Nki/Primpolem1Nki
Genetic
Background		 C57BL/6-Primpolem1Nki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Primpolem1Nki mutation (0 available); any Primpol mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:242620 )
N
• mice exhibit normal T and B cell development and class switching
abnormal somatic hypermutation frequency ( J:242620 )
• B cells exhibit a selective increase in C to G transversions

hematopoietic system
abnormal somatic hypermutation frequency ( J:242620 )
• B cells exhibit a selective increase in C to G transversions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory