Phenotypes associated with this allele

• Allele Symbol: Cuzd1^tm1Bag
• Allele Name: targeted mutation 1, Milan Bagchi
• Allele ID: MGI:5906132
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cuzd1^tm1Bag/Cuzd1^tm1Bag	involves: 129 * C57BL/6	MGI:5906140

Genotype
MGI:5906140

hm1

• Allelic Composition: Cuzd1^tm1Bag/Cuzd1^tm1Bag
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased mammary gland epithelial cell proliferation ( J:242064 )

• reduced proliferating ductal epithelial cells at puberty and during lactation

abnormal branching of the mammary ductal tree ( J:242064 )

• delayed epithelial tree expansion at puberty

• modestly reduced ductal branching in adult females at estrous stage (10 weeks old)

• severe deficiencies in tertiary branching during early pregnancy

• however, cap and body cells of terminal end buds are normal

abnormal mammary gland growth during lactation ( J:242064 )

• impaired alveolar development during late pregnancy and lactation

• sparsely distributed alveolar units with disrupted epithelial structure during lactation

impaired mammary gland growth during pregnancy ( J:242064 )

• severe deficiencies in tertiary branching during early pregnancy

• impaired alveolar development during late pregnancy and lactation

abnormal mammary gland alveolus morphology ( J:242064 )

• impaired alveolar development during late pregnancy and lactation

• sparsely distributed alveolar units with disrupted epithelial structure during lactation

• mice treated with estradiol, progesterone and prolactin fail to induce alveolus development unlike wild-type mice

cellular

decreased mammary gland epithelial cell proliferation ( J:242064 )

• reduced proliferating ductal epithelial cells at puberty and during lactation

maternal effect ( J:242064 )

• pups of homozygous dams die within 72 hours of birth

• however, fostered pups exhibit normal survival

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:242064 )

N • during puberty and pregnancy, mice exhibit normal serum levels of 17beta-estradiol, progesterone and prolactin

reproductive system

impaired mammary gland growth during pregnancy ( J:242064 )

• severe deficiencies in tertiary branching during early pregnancy

• impaired alveolar development during late pregnancy and lactation

endocrine/exocrine glands

decreased mammary gland epithelial cell proliferation ( J:242064 )

• reduced proliferating ductal epithelial cells at puberty and during lactation

abnormal branching of the mammary ductal tree ( J:242064 )

• delayed epithelial tree expansion at puberty

• modestly reduced ductal branching in adult females at estrous stage (10 weeks old)

• severe deficiencies in tertiary branching during early pregnancy

• however, cap and body cells of terminal end buds are normal

abnormal mammary gland growth during lactation ( J:242064 )

• impaired alveolar development during late pregnancy and lactation

• sparsely distributed alveolar units with disrupted epithelial structure during lactation

impaired mammary gland growth during pregnancy ( J:242064 )

• severe deficiencies in tertiary branching during early pregnancy

• impaired alveolar development during late pregnancy and lactation

abnormal mammary gland alveolus morphology ( J:242064 )

• impaired alveolar development during late pregnancy and lactation

• sparsely distributed alveolar units with disrupted epithelial structure during lactation

• mice treated with estradiol, progesterone and prolactin fail to induce alveolus development unlike wild-type mice