Phenotypes associated with this allele

• Allele Symbol: Rhot1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5906207
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rhot1^tm1c(EUCOMM)Wtsi/Rhot1^tm1c(EUCOMM)Wtsi Tg(Camk2a-cre)1Gsc/0	involves: C57BL/6Dnk * C57BL/6N * FVB/N	MGI:5906217

Genotype
MGI:5906217

cn1

• Allelic Composition: Rhot1^{tm1c(EUCOMM)Wtsi}/Rhot1^{tm1c(EUCOMM)Wtsi}; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: C57BL/6Dnk * C57BL/6N * FVB/N
• Cell Lines: EPD0066_2_F01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain size ( J:240500 )

• at 8 months

enlarged brain ventricles ( J:240500 )

small hippocampus ( J:240500 )

• at 8 months

thin cerebral cortex ( J:240500 )

• at 8 months

astrocytosis ( J:240500 )

• at 8 months

abnormal dendrite morphology ( J:240500 )

• decreased length at 8 months

• increased branchpoints in the proximal region of apical dendrites but decreased branchpoints in distal regions at 8 months

• however, dendrite morphology is normal at 4 months

decreased neuron number ( J:240500 )

• at 8 months

neurodegeneration ( J:240500 )

• at 8 months, mice exhibit enhanced loss of dendritic tree in CA1 pyramidal neurons and decreased numbers of neurons compared with control mice

abnormal axonal transport ( J:240500 )

• reduced mitochondria in the distal dendrites of CA1 neurons at 4 months