Analysis Tools
cardiovascular system
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• adrenergic stimulation with dobutamine results in reduced cardiac reserve with contractile dysfunction leading to a molecular phenotype that indicates dilated cardiomyopathy
• however under normal conditions, mice show no overt cardiac abnormalities at least up to 18 months of age
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• at 12 months of age, end-systolic pressure is lower, speed of ventricle contraction is decreased, but speed of pressure increase is normal, indicating a slower contraction in hearts
• ejection fraction of hearts is lower at 12 months, but not at 4-6 months and 18 months of age
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• both -dP/dt and Tau of hearts is different from controls at 12 months of age indicating impaired relaxation, although overall cardiac function is not weakened
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• increase in left ventricular internal diameter at the end of diastole in 6 month, but not 4 month old mice
• 6 month old mice injected with dobutamine show decreased septum thickness at end of diastole and end of systole and decreased cardiac output
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• ECG recording of mice under anesthesia shows decreased QRS amplitude at 6 months of age
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• sliding speed of isolated actin in an in vitro motility assay is 7% lower than in control actin
• calcium-sensitivity of force in papillary muscles is greater than in controls
• calcium-sensitivity of thin filaments is lower
• however, cardiomyocytes show normal contraction amplitude (% shortening), contraction speed or relaxation speed under basal conditions and do not behave differently from controls in response to increased calcium concentration or stimulation frequency
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• mice exhibit a reduced response to beta-adrenergic stimulation, with the dobutamine-mediated increases in heart rate, septal thickening,ejection fraction, and cardiac output lower than in controls at 18 months of age
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homeostasis/metabolism
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• mice exhibit a reduced response to beta-adrenergic stimulation, with the dobutamine-mediated increases in heart rate, septal thickening,ejection fraction, and cardiac output lower than in controls at 18 months of age
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muscle
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• adrenergic stimulation with dobutamine results in reduced cardiac reserve with contractile dysfunction leading to a molecular phenotype that indicates dilated cardiomyopathy
• however under normal conditions, mice show no overt cardiac abnormalities at least up to 18 months of age
|
|
• at 12 months of age, end-systolic pressure is lower, speed of ventricle contraction is decreased, but speed of pressure increase is normal, indicating a slower contraction in hearts
• ejection fraction of hearts is lower at 12 months, but not at 4-6 months and 18 months of age
|
|
• both -dP/dt and Tau of hearts is different from controls at 12 months of age indicating impaired relaxation, although overall cardiac function is not weakened
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy 1R | DOID:0110456 |
OMIM:613424 |
J:242344 | |
