mortality/aging
• no mice are present at E6.5
• however, mice are present at E3.5
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embryo
• impaired expansion and increased apoptosis of the blastocyst at 3 and 4 days in vitro
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• failure to form a monolayer of trophoblast giant cells at 3 and 4 days in vitro
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cellular
• increased apoptosis in the inner cell mass at 2 days in vitro
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• increased double-strand breaks
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