All Phenotypes Cdk12<tm1.2Mjfn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdk12^tm1.2Mjfn
targeted mutation 1.2, Ming-Ji Fann
MGI:5906608

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk12^tm1.2Mjfn/Cdk12^tm1.2Mjfn	involves: FVB/N	MGI:5906659
cn2	Cdk12^tm1.1Mjfn/Cdk12^tm1.2Mjfn Sox2^tm1Rlb/Sox2⁺	involves: 129S/SvEv * FVB/N	MGI:5906660

Allelic Composition	Cdk12^tm1.2Mjfn/Cdk12^tm1.2Mjfn
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk12^tm1.2Mjfn mutation (0 available); any Cdk12 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:242195 )

• no mice are present at E6.5

• however, mice are present at E3.5

embryo

abnormal inner cell mass morphology ( J:242195 )

• impaired expansion and increased apoptosis of the blastocyst at 3 and 4 days in vitro

abnormal trophoblast giant cell morphology ( J:242195 )

• failure to form a monolayer of trophoblast giant cells at 3 and 4 days in vitro

cellular

increased apoptosis ( J:242195 )

• increased apoptosis in the inner cell mass at 2 days in vitro

chromosomal instability ( J:242195 )

• increased double-strand breaks

Allelic Composition	Cdk12^tm1.1Mjfn/Cdk12^tm1.2Mjfn Sox2^tm1Rlb/Sox2⁺
Genetic Background	involves: 129S/SvEv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk12^tm1.1Mjfn mutation (0 available); any Cdk12 mutation (75 available)
Cdk12^tm1.2Mjfn mutation (0 available); any Cdk12 mutation (75 available)
Sox2^tm1Rlb mutation (0 available); any Sox2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:242195 )

• no mice are present at E6.5

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