Phenotypes associated with this allele

• Allele Symbol: Tet1^tuft
• Allele Name: tuft
• Allele ID: MGI:5906894
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tet1^tuft/Tet1^tuft	3H1/Lznf-Tet1^tuft	MGI:5906999
hm2	Tet1^tuft/Tet1^tuft	involves: 3H1/Lznf * BALB/c	MGI:5907001
hm3	Tet1^tuft/Tet1^tuft	involves: 3H1/Lznf * M. m. castaneus	MGI:5907003

Genotype
MGI:5906999

hm1

• Allelic Composition: Tet1^tuft/Tet1^tuft
• Genetic Background: 3H1/Lznf-Tet1^tuft

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal lamina terminalis morphology ( J:242827 )

• lesion may indicate improper closure of the anterior neuropore

abnormal neural tube closure ( J:242825 )

abnormal lateral ventricle morphology ( J:242827 )

• malformed in some mice due to lipoma

abnormal paraventricular hypothalamic nucleus morphology ( J:242827 )

• reduced cell counts

abnormal supraoptic nucleus morphology ( J:242827 )

• reduced cell counts

anencephaly ( J:242825 )

encephalomeningocele ( J:242825 )

craniofacial

abnormal interfrontal bone morphology ( J:242827 )

• larger, diamond-shaped, and much wider than in wild-type mice

bifid nose ( J:242825 )

• bifid nose

midline facial cleft ( J:242825 , J:242827 )

• in some mice (J:242827)

growth/size/body

bifid nose ( J:242825 )

• bifid nose

midline facial cleft ( J:242825 , J:242827 )

• in some mice (J:242827)

decreased body weight ( J:242825 )

• in some mice

• more pronounced in male than female mice

• however, some mice grow to normal weight after a month

decreased body length ( J:242825 )

• in some mice

• more pronounced in male than female mice

neoplasm

increased lipoma incidence ( J:242827 )

• mice develop a variably-sized, mid-line intracranial craniofacial lipoma of mesenchymal origin between the hemispheres and often protruded through the sagittal suture

• lipoma are apparent at birth and continue to grow in proportion to head size until the mouse matures

• lipoma emerge from the brain and through a hole in the skull

respiratory system

bifid nose ( J:242825 )

• bifid nose

vision/eye

ocular hypertelorism ( J:242825 , J:242827 )

• in some mice (J:242827)

pigmentation

irregular coat pigmentation ( J:242827 )

• blanching of hair over lipoma

skeleton

abnormal interfrontal bone morphology ( J:242827 )

• larger, diamond-shaped, and much wider than in wild-type mice

embryo

abnormal lamina terminalis morphology ( J:242827 )

• lesion may indicate improper closure of the anterior neuropore

abnormal neural tube closure ( J:242825 )

integument

irregular coat pigmentation ( J:242827 )

• blanching of hair over lipoma

Genotype
MGI:5907001

hm2

• Allelic Composition: Tet1^tuft/Tet1^tuft
• Genetic Background: involves: 3H1/Lznf * BALB/c

craniofacial

abnormal interfrontal bone morphology ( J:242827 )

• larger, diamond-shaped, and much wider than in wild-type mice

neoplasm

increased lipoma incidence ( J:242827 )

• in some mice

skeleton

abnormal interfrontal bone morphology ( J:242827 )

• larger, diamond-shaped, and much wider than in wild-type mice

vision/eye

ocular hypertelorism ( J:242827 )

• in some mice

Genotype
MGI:5907003

hm3

• Allelic Composition: Tet1^tuft/Tet1^tuft
• Genetic Background: involves: 3H1/Lznf * M. m. castaneus

neoplasm

increased lipoma incidence ( J:242827 )

• rarely

vision/eye

ocular hypertelorism ( J:242827 )

• rarely