Phenotypes associated with this allele

• Allele Symbol: App^tm1.1Tlyp
• Allele Name: targeted mutation 1.1, Tracy L Young-Pearse
• Allele ID: MGI:5906910
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	App^tm1.1Tlyp/App^tm1.1Tlyp Tg(CAG-cre/Esr1*)5Amc/?	B6.Cg-App^tm1.1Tlyp Tg(CAG-cre/Esr1*)5Amc	MGI:6114982

Genotype
MGI:6114982

cn1

• Allelic Composition: App^tm1.1Tlyp/App^tm1.1Tlyp; Tg(CAG-cre/Esr1*)5Amc/?
• Genetic Background: B6.Cg-App^tm1.1Tlyp Tg(CAG-cre/Esr1*)5Amc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal stratification in cerebral cortex ( J:241006 )

• in a subset of embryos, some TBR1+ cells (expressed in the lower cortical layer) are observed below the cortical plate after tamoxifen treatment

• following tamoxifen treatment, the majority of Reelin+ cells (expressed in the marginal zone) in some embryonic brains are displaced below the cortical plate, and, in other brains, Reelin+ cells are displaced to the intermediate zone

• number and morphology of astrocytes and microglia are similar to wild-type in the hippocampus and cerebral cortex following tamoxifen treatment at E12, 13, and 14 (harvested on E18)