About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Srebf2tm1Jdh
targeted mutation 1, Jay D Horton
MGI:5907035
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Srebf2tm1Jdh/Srebf2tm1Jdh
Speer6-ps1Tg(Alb-cre)21Mgn/?
involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:5908398


Genotype
MGI:5908398
cn1
Allelic
Composition
Srebf2tm1Jdh/Srebf2tm1Jdh
Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Srebf2tm1Jdh mutation (1 available); any Srebf2 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice weigh less than controls, however liver weights are unchanged

homeostasis/metabolism
• rate of sterol synthesis in the liver is decreased by 59%
• rate of fatty acid synthesis in the liver is decreased by 68%
• plasma cholesterol level is reduced by 68%
• plasma triglyceride level is reduced by 50%
• liver cholesterol level is reduced by 20%
• dietary supplementation with 0.2% cholesterol increased liver cholesterol concentrations to control levels
• liver triglyceride level is reduced by 76%
• triglyceride secretion rate from liver is reduced by 29%

liver/biliary system
• liver cholesterol level is reduced by 20%
• dietary supplementation with 0.2% cholesterol increased liver cholesterol concentrations to control levels
• liver triglyceride level is reduced by 76%
• triglyceride secretion rate from liver is reduced by 29%





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory