Phenotypes associated with this allele

• Allele Symbol: Vps13c^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:5907128
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Vps13c^tm1.1Geno/Vps13c^tm1.1Geno	involves: C57BL/6	MGI:5907185

Genotype
MGI:5907185

cn1

• Allelic Composition: Vps13c^tm1.1Geno/Vps13c^tm1.1Geno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:241413 , J:241413 )

N • at 19-21 weeks of age in females and males on high fat diet and males on regular chow (J:241413)

♀ • at 19-21 weeks of age on regular chow (J:241413)

impaired glucose tolerance ( J:241413 , J:241413 )

• as measured via intraperitoneal glucose tolerance (IPGTT) (J:241413)

♂ • reduced at 20 weeks of age on regular chow (J:241413)

♂ • up to 16 weeks of age on regular chow and up to 20 weeks on high fat diet (J:241413)

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:241413 , J:241413 )

N • in females and males on high fat diet and males on regular chow (J:241413)

♀ • suggested by HOMA2 analysis of fasting glycemia with corresponding insulin plasma concentration on regular chow (J:241413)