Phenotypes associated with this allele

• Allele Symbol: Abhd6^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5907201
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abhd6^tm1c(EUCOMM)Hmgu/Abhd6^tm1c(EUCOMM)Hmgu Tg(Ins1-cre/ERT)1Lphi/0	involves: C57BL/6N * CD-1	MGI:6276028

Genotype
MGI:6276028

cn1

• Allelic Composition: Abhd6^{tm1c(EUCOMM)Hmgu}/Abhd6^{tm1c(EUCOMM)Hmgu}; Tg(Ins1-cre/ERT)1Lphi/0
• Genetic Background: involves: C57BL/6N * CD-1
• Cell Lines: HEPD0651_8_C07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased insulin secretion ( J:215257 )

• islets from tamoxifen-treated mice show enhanced glucose-stimulated insulin secretion

• however, tamoxifen treated mice show normal body weight, food intake and no changes in beta cell mass

homeostasis/metabolism

increased insulin secretion ( J:215257 )

• islets from tamoxifen-treated mice show enhanced glucose-stimulated insulin secretion

• however, tamoxifen treated mice show normal body weight, food intake and no changes in beta cell mass

increased circulating insulin level ( J:215257 )

• tamoxifen-treated males show elevated insulinemia during oral glucose tolerance test

improved glucose tolerance ( J:215257 )

• tamoxifen-treated males show slightly improved glucose tolerance during oral glucose tolerance test