All Phenotypes Cfap157<tm1b(EUCOMM)Hmgu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cfap157^{tm1b(EUCOMM)Hmgu}
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:5907281

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfap157^{tm1b(EUCOMM)Hmgu}/Cfap157^{tm1b(EUCOMM)Hmgu}	involves: C57BL/6 * SJL	MGI:6104240

Allelic Composition	Cfap157^{tm1b(EUCOMM)Hmgu}/Cfap157^{tm1b(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfap157^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Cfap157 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:237484 )

• bulge in proximal flagellum

abnormal sperm midpiece morphology ( J:237484 )

• axonemal loop in 93% of sperm

• surplus cytoplasm in axonemal loop

• bulge in 6% of sperm

• ectopic fibrous sheath close to sperm head and reduced sheath in principal piece in 80% of sperm

• accumulation of mitochondria near axonemal link

abnormal sperm head morphology ( J:237484 )

• dislocated in 75% of sperm

absent sperm head ( J:237484 )

• in 12% of sperm

decreased male germ cell number ( J:237484 )

abnormal sperm motility ( J:237484 )

• reduced

• abnormal (twitching or local circular movement)

decreased hyperactivated sperm motility ( J:237484 )

• inefficient binding to eggs and barely moving eggs in vitro

abnormal cauda epididymis morphology ( J:237484 )

• fewer sperm

male infertility ( J:237484 )

• continuous matings (3-5 months) yielded no offspring

• left vaginal plugs in timed matings but produced no offspring

cellular

abnormal cell morphology ( J:237484 )

• sperm isolated from cauda epididymis

abnormal sperm flagellum morphology ( J:237484 )

• bulge in proximal flagellum

abnormal sperm midpiece morphology ( J:237484 )

• axonemal loop in 93% of sperm

• surplus cytoplasm in axonemal loop

• bulge in 6% of sperm

• ectopic fibrous sheath close to sperm head and reduced sheath in principal piece in 80% of sperm

• accumulation of mitochondria near axonemal link

abnormal sperm head morphology ( J:237484 )

• dislocated in 75% of sperm

absent sperm head ( J:237484 )

• in 12% of sperm

decreased male germ cell number ( J:237484 )

abnormal sperm motility ( J:237484 )

• reduced

• abnormal (twitching or local circular movement)

decreased hyperactivated sperm motility ( J:237484 )

• inefficient binding to eggs and barely moving eggs in vitro

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24