Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Mlip)Dzw}
• Allele Name: targeted mutation 1, Da-Zhi Wang
• Allele ID: MGI:5907349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-Mlip)Dzw/Gt(ROSA)26Sor^+ Tg(Tnnt2-cre)5Blh/0	involves: C57BL/6 * DBA/2	MGI:5907356

Genotype
MGI:5907356

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Mlip)Dzw}/Gt(ROSA)26Sor⁺; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:227485 )

N • no cardiac phenotype under baseline conditions

decreased response of heart to induced stress ( J:227485 )

• at 4 weeks after transverse aortic constriction (TAC) cardiac hypertrophy is suppressed and cardiac function is preserved compared to similarly treated wild-type controls

• cardiac function is preserved and no signs of left ventricular dilation are seen after 10 weeks of TAC unlike in controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:227485 )

• at 4 weeks after transverse aortic constriction (TAC) cardiac hypertrophy is suppressed and cardiac function is preserved compared to similarly treated wild-type controls

• cardiac function is preserved and no signs of left ventricular dilation are seen after 10 weeks of TAC unlike in controls