Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-LPL*)357Ijg transgene insertion 357, Ira J Goldberg MGI:5907463 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males begin to die after 20 weeks of age and all die by 60 weeks of age
• breeding females begin to die around 4 weeks of age and all die by 32 weeks of age
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• disarrayed cardiomyocyte architecture with increased mitochondria
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• increase in intracellular neutral lipid in hearts from 24-hour fasted mice
• 58.9% increase in cholesteryl ester and a 24.7% increase in free fatty acid in hearts
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• lipid accumulation within myocytes
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• 4 month old males exhibit enlarged hearts
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• females exhibit an increase in heart weight
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• hearts exhibit 54% more VLDL-triglyceride uptake in the absence of heparin and 26% more uptake in the presence of heparin than controls
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• left ventricular systolic function is impaired
• however, no increase in ventricular wall thickness is seen
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• heparinized mice exhibit faster clearance of VLDL from the plasma than single Lpl homozygotes
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• increase in intracellular neutral lipid in hearts from 24-hour fasted mice
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• 24.7% increase in free fatty acid in hearts
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• disarrayed cardiomyocyte architecture with increased mitochondria
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• lipid accumulation within myocytes
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• left ventricular systolic function is impaired
• however, no increase in ventricular wall thickness is seen
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• 4 month old males exhibit enlarged hearts
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• females exhibit an increase in heart weight
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cardiomyopathy | DOID:0050700 | J:134550 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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