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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf14tm1.1Kro
targeted mutation 1.1, Mitchell Kronenberg
MGI:5907516
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Commd10Tg(Vav1-icre)A2Kio/?
Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro 		involves: C57BL/6NCrl * C57BL/10 * CBA * SJL MGI:5908557


Genotype
MGI:5908557
cn1
Allelic
Composition		 Commd10Tg(Vav1-icre)A2Kio/?
Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
Genetic
Background		 involves: C57BL/6NCrl * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Tnfrsf14tm1.1Kro mutation (1 available); any Tnfrsf14 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Herpesvirales infection ( J:243038 )
• following corneal inoculation of HSV1, corneas have lower viral titers as compared to controls
• myeloid cell infiltration into the cornea 14 days post HSV1 infection is reduced as compared to controls

behavior/neurological
abnormal blinking ( J:243038 )
• following corneal inoculation of HSV1, corneal reflexes (as measured by corneal touch threshold) are largely retained in contrast to infected controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory