Phenotypes associated with this allele

• Allele Symbol: Tg(HBx-HCV)C5Tto
• Allele Name: transgene insertion C5, Takeshi Tokuhisa
• Allele ID: MGI:5907641
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(HBx-HCV)C5Tto/0	B6.Cg-Tg(HBx-HCV)C5Tto	MGI:5907644
tg2	Tg(HBx-HCV)C5Tto/0	involves: C57BL/6 * DBA/2	MGI:5907647

Genotype
MGI:5907644

tg1

• Allelic Composition: Tg(HBx-HCV)C5Tto/0
• Genetic Background: B6.Cg-Tg(HBx-HCV)C5Tto

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:243110 )

• mice exhibit slightly higher alanine aminotransaminase levels in response to Fas-mediated liver cell injury than controls

abnormal response to injury ( J:243110 )

• an initial injection of anti-Fas antibody to induce liver cell injury induces resistance of liver cells to the second injection of anti-Fas antibody as in controls, however, recovery time of transgenic mice from insensitivity is about half of that in controls

Genotype
MGI:5907647

tg2

• Allelic Composition: Tg(HBx-HCV)C5Tto/0
• Genetic Background: involves: C57BL/6 * DBA/2

cardiovascular system

abnormal cardiac muscle tissue morphology ( J:105313 )

♂ • myofiber disorganization and disarray

abnormal heart morphology ( J:105313 )

♂ • disarray of myofibers, scarcity of myofibrils, vacuolization and pleomorphic nuclear changes are seen in hearts at 12 months of age

♂ • hearts exhibit increased number of bizarre-shaped mitochondria, aggregation of mitochondria, and cavity formation of mitochondria

♂ • however, no infiltration of lymphocytes is seen at 6, 9, or 12 months of age, indicating no myocarditis

abnormal myocardial fiber morphology ( J:105313 )

♂ • cardiomyocytes exhibit irregular shaped nuclei and myofilament loss

increased myocardial fiber size ( J:105313 )

♂ • hypertrophy of cardiomyocytes at 12 months of age

♂ • cardiomyocyte cross-sectional area is larger

dilated heart left ventricle ( J:105313 )

♂ • the left ventricular cavity is larger

abnormal heart ventricles weight ( J:105313 )

♂ • ventricular weight-to-body weight ratio is higher at 12 months of age

cardiac fibrosis ( J:105313 )

♂

decreased cardiac muscle contractility ( J:105313 )

♂ • mice exhibit decreased fraction shortening and ejection fraction at 12 weeks of age

♂ • however, heart rate and blood pressure are normal

abnormal heart echocardiography feature ( J:105313 )

♂ • mice exhibit increased left ventricular end-diastolic and end-systolic dimension, decreased fractional shortening and ejection fraction, increased E wave/A wave velocity ratio at 12 months of age

cardiomyopathy ( J:105313 )

♂

cellular

abnormal mitochondrial shape ( J:105313 )

♂ • hearts show increased number of bizarre-shaped mitochondria

muscle

abnormal cardiac muscle tissue morphology ( J:105313 )

♂ • myofiber disorganization and disarray

abnormal myocardial fiber morphology ( J:105313 )

♂ • cardiomyocytes exhibit irregular shaped nuclei and myofilament loss

increased myocardial fiber size ( J:105313 )

♂ • hypertrophy of cardiomyocytes at 12 months of age

♂ • cardiomyocyte cross-sectional area is larger

decreased cardiac muscle contractility ( J:105313 )

♂ • mice exhibit decreased fraction shortening and ejection fraction at 12 weeks of age

♂ • however, heart rate and blood pressure are normal

cardiomyopathy ( J:105313 )

♂

abnormal Z line morphology ( J:105313 )

♂ • hearts show Z-band abnormalities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiomyopathy		DOID:0050700		J:105313