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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp407em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5907859
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp407em1(IMPC)J/Zfp407em1(IMPC)J C57BL/6NJ-Zfp407em1(IMPC)J/Mmjax MGI:6263914
ht2
 		Zfp407em1(IMPC)J/Zfp407+ C57BL/6NJ-Zfp407em1(IMPC)J/Mmjax MGI:6263913


Genotype
MGI:6263914
hm1
Allelic
Composition		 Zfp407em1(IMPC)J/Zfp407em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Zfp407em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp407em1(IMPC)J mutation (2 available); any Zfp407 mutation (102 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Zfp407em1(IMPC)J/Zfp407em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as stalled cleavage stage embryos. Mutants fail to hatch from the zona with no further development in culture.

embryo
failure of blastocyst formation ( J:279207 )
• in vitro, embryos fail to hatch and show no further development after 3 days in culture
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture
embryonic growth arrest ( J:279207 )
• homozygous embryos recovered at E3.5 appear as stalled cleavage stage embryos
• in vitro, embryos do not develop further after 3 days in culture

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• homozygous embryos are present in expected Mendelian ratios at E3.5 but appear as stalled cleavage stage embryos; no embryos are recovered at E7.5




Genotype
MGI:6263913
ht2
Allelic
Composition		 Zfp407em1(IMPC)J/Zfp407+
Genetic
Background		 C57BL/6NJ-Zfp407em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp407em1(IMPC)J mutation (2 available); any Zfp407 mutation (102 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:211773 )
IMPC - JAX




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory