Phenotypes associated with this allele

• Allele Symbol: Plekha7^tm1.1Janc
• Allele Name: targeted mutation 1.1, Jan E Carette
• Allele ID: MGI:5907899
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plekha7^tm1.1Janc/Plekha7^tm1.1Janc	involves: C57BL/6	MGI:5907900

Genotype
MGI:5907900

hm1

• Allelic Composition: Plekha7^tm1.1Janc/Plekha7^tm1.1Janc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:227858 )

• following acute lethal MRSA infection initial hypothermia is similar to controls but only null mice show enhanced, significant recovery of core temperature by 24h post infection and more fully recover without antibiotic treatment

• when challenged with 3-fold higher inoculum mean time to death is longer compared to wild-type mice

immune system

decreased susceptibility to bacterial infection ( J:227858 )

• while early lesions are similar to controls, at 14 days after infection with S. aureus (WT USA300 LAC) lesions are resolved with significantly less tissue loss

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:227858 )

• following acute lethal MRSA infection initial hypothermia is similar to controls but only null mice show enhanced, significant recovery of core temperature by 24h post infection and more fully recover without antibiotic treatment

• when challenged with 3-fold higher inoculum mean time to death is longer compared to wild-type mice