Phenotypes associated with this allele

• Allele Symbol: Uhrf2^em1Yoz
• Allele Name: endonuclease-mediated mutation 1, Yongxiang Zhao
• Allele ID: MGI:5907901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uhrf2^em1Yoz/Uhrf2^em1Yoz	FVB/N-Uhrf2^em1Yoz	MGI:5907983

Genotype
MGI:5907983

hm1

• Allelic Composition: Uhrf2^em1Yoz/Uhrf2^em1Yoz
• Genetic Background: FVB/N-Uhrf2^em1Yoz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:241384 )

• impaired contextual fear memory acquisition and retention judging from less time spent in freezing response during interval in unconditioned stimulus/conditioned stimulus (US/CS; foot shock/shock chamber) experiments

abnormal spatial reference memory ( J:241384 )

• significantly less time spent in target quadrant during Morris water maze test

cellular

abnormal DNA methylation ( J:241384 )

• moderate but significant reduction of 5hmC (5-hydroxymethylcytosine) in the brain (from 0.386% in wild-type to 0.352%) and moderate reduction in cerebellum and cortex

• small but significant reduction of 5mC (5-methylcytosine) in cortex

• immunohistochemistry showed reduced level of 5hmC in hippocampus