Phenotypes associated with this allele

• Allele Symbol: Rr199^em1Takas
• Allele Name: endonuclease-mediated mutation 1, Shuji Takada
• Allele ID: MGI:5908024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr199^em1Takas/Rr199^+	involves: C57BL/6 * DBA/2 * JF1	MGI:5908113

Genotype
MGI:5908113

ht1

• Allelic Composition: Rr199^em1Takas/Rr199⁺
• Genetic Background: involves: C57BL/6 * DBA/2 * JF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:241393 )

N • no change in parent of origin in expression of alleles of imprinted genes

N • no difference in DNA methylation pattern according to bisulphite sequencing analysis

abnormal epigenetic regulation of gene expression ( J:241393 )

• Rtl1 expression downregulated in mice with maternally inherited allele

• Dio3 expression levels significantly lower in mice with paternally inherited allele