All Phenotypes Gt(ROSA)26Sor<tm2(CARD11*L225LI)Jrld> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd	MGI:5908453
cn2	Bcl10^tm1Mak/Bcl10^tm1Mak Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd	MGI:5908454
cn3	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺ Malt1^tm1Mak/Malt1^tm1Mak	involves: 129P2/OlaHsd	MGI:5908455

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:228288 )

• all die by P6

neoplasm

increased B cell derived lymphoma incidence ( J:228288 )

• blastoid cells that infiltrate solid organs are seen indicating high-grade lymphoma

• blastoid B cells express low levels of IL7 or CD25 indicating the disease does not resemble acute B-cell lineage leukemia

immune system

increased B cell number ( J:228288 )

increased plasma cell number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal plasmablast number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal spleen morphology ( J:228288 )

• spleens contain homogenous populations of large cells with prominent nucleoli and high proliferation indices

enlarged spleen ( J:228288 )

• massive

spleen hyperplasia ( J:228288 )

• high proliferation indices

abnormal B cell activation ( J:228288 )

• recombined B cells exhibit an activated phenotype with high CD80 and Sca-1 expression and elevated CD43 levels

increased B cell proliferation ( J:228288 )

• B cells proliferate vigorously in the absence of any specific B cell survival or mitogenic factors for at least 10 days in culture

• high proliferation indices in the spleen

enlarged lymph nodes ( J:228288 )

hematopoietic system

abnormal bone marrow cell number ( J:228288 )

• massive reduction in the B220+ IgM- compartment in the bone marrow indicating infiltration by peripheral blastoid B cells

increased B cell number ( J:228288 )

increased plasma cell number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal plasmablast number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal spleen morphology ( J:228288 )

• spleens contain homogenous populations of large cells with prominent nucleoli and high proliferation indices

enlarged spleen ( J:228288 )

• massive

spleen hyperplasia ( J:228288 )

• high proliferation indices

abnormal B cell activation ( J:228288 )

• recombined B cells exhibit an activated phenotype with high CD80 and Sca-1 expression and elevated CD43 levels

increased B cell proliferation ( J:228288 )

• B cells proliferate vigorously in the absence of any specific B cell survival or mitogenic factors for at least 10 days in culture

• high proliferation indices in the spleen

cellular

increased B cell proliferation ( J:228288 )

• B cells proliferate vigorously in the absence of any specific B cell survival or mitogenic factors for at least 10 days in culture

• high proliferation indices in the spleen

growth/size/body

enlarged spleen ( J:228288 )

• massive

spleen hyperplasia ( J:228288 )

• high proliferation indices

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diffuse large B-cell lymphoma		DOID:0050745		J:228288

Allelic Composition	Bcl10^tm1Mak/Bcl10^tm1Mak Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl10^tm1Mak mutation (1 available); any Bcl10 mutation (16 available)
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:228288 )

N	• absence of Bcl10 expression rescues the early lethality seen in mutant mice wild-type for Bcl10

immune system

immune system phenotype ( J:228288 )

N	• absence of Bcl10 expression rescues the pathological B-cell activation, differentiation, and malignant proliferation seen in mutant mice wild-type for Bcl10

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺ Malt1^tm1Mak/Malt1^tm1Mak
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Malt1^tm1Mak mutation (1 available); any Malt1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:228288 )

N	• absence of Malt1 expression rescues the early lethality seen in mutant mice wild-type for Malt1

immune system

immune system phenotype ( J:228288 )

N	• absence of Malt1 expression rescues the pathological B-cell activation, differentiation, and malignant proliferation seen in mutant mice wild-type for Malt1

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