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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Mybpc3*)24Rbns
transgene insertion 24, Jeffrey Robbins
MGI:5908461
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Mybpc3*)24Rbns/0 Not Specified MGI:5908514


Genotype
MGI:5908514
tg1
Allelic
Composition
Tg(Myh6-Mybpc3*)24Rbns/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• adult hearts appear globose
• mitochondrial abnormalities in cardiomyocytes with both the numbers and organization showing alterations in 35 week old mice and as early as 12 weeks of age
• increase in heart weight/body weight ratios in 50 week old mice, with an approximate 20% increase by 12 months
• mild hypertrophy in the papillary muscle and the left ventricular free wall in adult hearts
• heart rates in response to exercise are decreased
• however, no arrhythmias are seen during or after exercise
• skinned fibers from the left ventricular papillary muscles of young adults show decreased maximal unloading shortening velocity and decreased maximal relative power output
• however, hearts exhibit unchanged cardiac work, time to peak pressure, relaxation, and contractility

behavior/neurological
• mice exhibit impaired exercise capacity, with decreased heart rates in response to exercise

homeostasis/metabolism
• mice exhibit impaired exercise capacity, with decreased heart rates in response to exercise

muscle
• mitochondrial abnormalities in cardiomyocytes with both the numbers and organization showing alterations in 35 week old mice and as early as 12 weeks of age
• cardiac sarcomere arrangements are altered, with sarcomeres out of register with each other and the normal pattern disrupted, in 35 week old mice and as early as 12 weeks of age
• Z lines do not retain their normal arrangements between the cardiac sarcomeric rows

cellular
• mitochondrial abnormalities in cardiomyocytes with both the numbers and organization showing alterations in 35 week old mice and as early as 12 weeks of age

growth/size/body
• increase in heart weight/body weight ratios in 50 week old mice, with an approximate 20% increase by 12 months
• mild hypertrophy in the papillary muscle and the left ventricular free wall in adult hearts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 4 DOID:0110310 OMIM:115197
J:59702





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory