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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ssu2tm1.1Xmx
targeted mutation 1.1, Xiangming Xu
MGI:5908700
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ssu2tm1.1Xmx/Ssu2tm1.1Xmx involves: 129S6/SvEvTac * C57BL/6J MGI:5908863
ht2
 		Ssu2tm1.1Xmx/Ssu2+ involves: 129S6/SvEvTac * C57BL/6J MGI:5908862


Genotype
MGI:5908863
hm1
Allelic
Composition		 Ssu2tm1.1Xmx/Ssu2tm1.1Xmx
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssu2tm1.1Xmx mutation (0 available); any Ssu2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth morphology ( J:240559 )
• abnormal collagenous attachment to the gum
abnormal dental pulp cavity morphology ( J:240559 )
• narrowed dental pulp cavities
abnormal dental pulp morphology ( J:240559 )
• increased number of pulpal cells
increased odontoblast number ( J:240559 )
• significantly increased numbers of odontoblasts in the pulp cavity
abnormal dentin morphology ( J:240559 )
• increased dentin thickness
• anomalies in the number and organization of dentinal tubules
abnormal dentin mineralization ( J:240559 )
• dysplasia of the mineralized dentin
• mineralized dentin width is higher
abnormal predentin morphology ( J:240559 )
• reduced width of the predentin zone
abnormal tooth attrition ( J:240559 )
• abnormal tooth attrition whether fed normal diet or a soft diet

growth/size/body
abnormal tooth morphology ( J:240559 )
• abnormal collagenous attachment to the gum
abnormal dental pulp cavity morphology ( J:240559 )
• narrowed dental pulp cavities
abnormal dental pulp morphology ( J:240559 )
• increased number of pulpal cells
increased odontoblast number ( J:240559 )
• significantly increased numbers of odontoblasts in the pulp cavity
abnormal dentin morphology ( J:240559 )
• increased dentin thickness
• anomalies in the number and organization of dentinal tubules
abnormal dentin mineralization ( J:240559 )
• dysplasia of the mineralized dentin
• mineralized dentin width is higher
abnormal predentin morphology ( J:240559 )
• reduced width of the predentin zone
abnormal tooth attrition ( J:240559 )
• abnormal tooth attrition whether fed normal diet or a soft diet

skeleton
abnormal tooth morphology ( J:240559 )
• abnormal collagenous attachment to the gum
abnormal dental pulp cavity morphology ( J:240559 )
• narrowed dental pulp cavities
abnormal dental pulp morphology ( J:240559 )
• increased number of pulpal cells
increased odontoblast number ( J:240559 )
• significantly increased numbers of odontoblasts in the pulp cavity
abnormal dentin morphology ( J:240559 )
• increased dentin thickness
• anomalies in the number and organization of dentinal tubules
abnormal dentin mineralization ( J:240559 )
• dysplasia of the mineralized dentin
• mineralized dentin width is higher
abnormal predentin morphology ( J:240559 )
• reduced width of the predentin zone
abnormal tooth attrition ( J:240559 )
• abnormal tooth attrition whether fed normal diet or a soft diet

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
dentin dysplasia DOID:701 OMIM:125400
OMIM:125420
 J:240559




Genotype
MGI:5908862
ht2
Allelic
Composition		 Ssu2tm1.1Xmx/Ssu2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssu2tm1.1Xmx mutation (0 available); any Ssu2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth morphology ( J:240559 )
• abnormal collagenous attachment to the gum
abnormal dental pulp cavity morphology ( J:240559 )
• intermediately narrowed dental pulp cavities
abnormal dental pulp morphology ( J:240559 )
• increased number of pulpal cells
abnormal dentin morphology ( J:240559 )
• intermediate increased thickness
abnormal dentin mineralization ( J:240559 )
• mineralized dentin width is higher
abnormal predentin morphology ( J:240559 )
• reduced width of the predentin zone
abnormal tooth attrition ( J:240559 )
• intermediate abnormal tooth attrition whether fed normal diet or a soft diet

growth/size/body
abnormal tooth morphology ( J:240559 )
• abnormal collagenous attachment to the gum
abnormal dental pulp cavity morphology ( J:240559 )
• intermediately narrowed dental pulp cavities
abnormal dental pulp morphology ( J:240559 )
• increased number of pulpal cells
increased odontoblast number ( J:240559 )
abnormal dentin morphology ( J:240559 )
• intermediate increased thickness
abnormal dentin mineralization ( J:240559 )
• mineralized dentin width is higher
abnormal predentin morphology ( J:240559 )
• reduced width of the predentin zone
abnormal tooth attrition ( J:240559 )
• intermediate abnormal tooth attrition whether fed normal diet or a soft diet

skeleton
abnormal tooth morphology ( J:240559 )
• abnormal collagenous attachment to the gum
abnormal dental pulp cavity morphology ( J:240559 )
• intermediately narrowed dental pulp cavities
abnormal dental pulp morphology ( J:240559 )
• increased number of pulpal cells
abnormal dentin morphology ( J:240559 )
• intermediate increased thickness
abnormal dentin mineralization ( J:240559 )
• mineralized dentin width is higher
abnormal predentin morphology ( J:240559 )
• reduced width of the predentin zone
abnormal tooth attrition ( J:240559 )
• intermediate abnormal tooth attrition whether fed normal diet or a soft diet

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
dentin dysplasia DOID:701 OMIM:125400
OMIM:125420
 J:240559




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory