Phenotypes associated with this allele

• Allele Symbol: Pcbp2^tm1.2Salr
• Allele Name: targeted mutation 1.2, Stephen A Liebhaber
• Allele ID: MGI:5908914
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcbp2^tm1.2Salr/Pcbp2^tm1.2Salr	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5909012
ht2	Pcbp2^tm1.2Salr/Pcbp2^+	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5909013
cx3	Pcbp1^em2Salr/Pcbp1^+ Pcbp2^tm1.2Salr/Pcbp2^+	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5909014

Genotype
MGI:5909012

hm1

• Allelic Composition: Pcbp2^tm1.2Salr/Pcbp2^tm1.2Salr
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:235912 )

• mice die between E12.5 and E14.5 to E15.5

postnatal lethality, complete penetrance ( J:235912 )

• no mice are present at 7 days of life

embryonic lethality during organogenesis, incomplete penetrance ( J:235912 )

• mice die between E12.5 and E14.5 to E15.5

cardiovascular system

hemorrhage ( J:235912 )

• large focal at E13.5 in most mice

• microhemorrhage in the minority of E12.5 embryos

homeostasis/metabolism

subcutaneous edema ( J:235912 )

• at E13.5 in most mice

integument

subcutaneous edema ( J:235912 )

• at E13.5 in most mice

Genotype
MGI:5909013

ht2

• Allelic Composition: Pcbp2^tm1.2Salr/Pcbp2⁺
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

hematopoietic system

abnormal erythroblast morphology ( J:235912 )

• increase in immature (S1) cells with a decrease in more mature (S3 and S4/S5) erythroblasts

• however, there is no impact on the number of red blood cells

abnormal platelet cell number ( J:235912 )

• trend toward lower mean platelet counts

growth/size/body

decreased body weight ( J:235912 )

• prior to weaning and through adulthood in female and male mice

• however, crown-rump length and placental diameter are normal

Genotype
MGI:5909014

cx3

• Allelic Composition: Pcbp1^em2Salr/Pcbp1⁺; Pcbp2^tm1.2Salr/Pcbp2⁺
• Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * FVB/N

mortality/aging

postnatal lethality, incomplete penetrance ( J:235912 )

• only 1 mouse survived beyond the first week of life

prenatal lethality, incomplete penetrance ( J:235912 )

• fewer than expected mice are born alive

growth/size/body

decreased body weight ( J:235912 )

• in surviving mice