Phenotypes associated with this allele

• Allele Symbol: Ostn^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:5908915
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ostn^tm1.1Geno/Ostn^tm1.1Geno	involves: C57BL/6	MGI:5908916

Genotype
MGI:5908916

hm1

• Allelic Composition: Ostn^tm1.1Geno/Ostn^tm1.1Geno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:228285 )

• significant deficit in exercise tolerance with a reduction in duration, distance and overall work load in a treadmill assay

• show a lower mean velocity, duration of running, and distance run on a running wheel

• treatment with osteocrin rescues activity on a running wheel

decreased oxygen consumption ( J:228285 )

• decreased VO2 max on a stationary treadmill

• treatment with osteocrin for 3 weeks restores VO2 max to wild-type levels

muscle

abnormal skeletal muscle fiber type ratio ( J:228285 )

• shift toward more pure glycolytic type IIb fibers that is more marked in exercised mice

• however in sedentary mice, distribution of fiber types is similar to wild-type

cellular

decreased mitochondrial size ( J:228285 )

behavior/neurological

impaired exercise endurance ( J:228285 )

• significant deficit in exercise tolerance with a reduction in duration, distance and overall work load in a treadmill assay

• show a lower mean velocity, duration of running, and distance run on a running wheel

• treatment with osteocrin rescues activity on a running wheel