Phenotypes associated with this allele

• Allele Symbol: Mgst2^{Gt(OST22210)Lex}
• Allele Name: gene trap OST22210, Lexicon Genetics
• Allele ID: MGI:5908940
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgst2^Gt(OST22210)Lex/Mgst2^Gt(OST22210)Lex	involves: 129S5/SvEvBrd	MGI:5908949

Genotype
MGI:5908949

hm1

• Allelic Composition: Mgst2^{Gt(OST22210)Lex}/Mgst2^{Gt(OST22210)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:228296 )

• decrease in sensitivity to tunicamycin-induced and 5-fluorouracil-induced mortality

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:228296 )

• decrease in sensitivity to tunicamycin-induced and 5-fluorouracil-induced mortality

decreased physiological sensitivity to xenobiotic ( J:228296 )

• decrease in the area of necrotic vacuoles in a model of tunicamycin-induced kidney injury

cellular

decreased fibroblast apoptosis ( J:228296 )

• decrease in ER stress induced apoptosis in MEFs

decreased endoplasmic reticulum stress ( J:228296 )

• resistance to induced ER stress