Phenotypes associated with this allele

• Allele Symbol: Exoc2^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5909206
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exoc2^em1(IMPC)J/Exoc2^em1(IMPC)J	C57BL/6NJ-Exoc2^em1(IMPC)J/Mmjax	MGI:6394289

Genotype
MGI:6394289

hm1

• Allelic Composition: Exoc2^em1(IMPC)J/Exoc2^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Exoc2^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Exoc2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exoc2^em1(IMPC)J/Exoc2^em1(IMPC)J mice exhibit embryonic lethality after E3.5 but before E7.5. Blastocysts grown in vitro fail to hatch from the zona pellucida.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• normal blastocysts are recovered at approximate Mendelian ratios at E3.5 (33% versus expected 25%, n=33); no homozygous embryos are recovered at E7.5