cardiovascular system
• papillary muscle fibers show a change in the interfilament spacing in rigor, with the lattice spacing being reduced in the myocardium
• however, no alterations in actomyosin cross-bridge mass distribution are seen
|
• increase in size of cardiomyocytes
|
• heart-to-body weight ratio is increased
|
• decrease in number of nuclei indicating cardiac hypertrophy
• left ventricular volumes in diastole and systole are larger, indicating development of eccentric hypertrophy
|
• left ventricle exhibits myofilament disarray and signs of fibrosis
|
• left ventricle exhibits signs of fibrosis
(J:178377)
• however, hearts exhibit normal size in 10-12 month old males
(J:178377)
• hearts exhibit severe fibrosis as early as 6 months of age
(J:202154)
|
• during inferior vena cava occlusion, the load-independent end-systolic elastance is higher compare to controls
|
• stroke work is increased
|
• increase in left ventricular end diastolic volume with higher left ventricular end systolic pressure, indicating higher heart contractility
|
• echocardiography shows larger left ventricular volumes in diastole and systole, however left ventricle posterior wall and anterior wall dimensions are normal
|
• higher left ventricular end systolic pressure
|
• muscle fibers exhibit increased stiffness
(J:178377)
• skinned papillary muscle show a 20-35% decrease in maximal tension
(J:202154)
• papillary muscle shows a small, but significant, increase in the calcium sensitivity of force
(J:202154)
• level of passive tension is increased in skinned papillary muscle, suggesting higher stiffness (increased resistance to stretch) in the myocardium
(J:202154)
|
muscle
• papillary muscle fibers show a change in the interfilament spacing in rigor, with the lattice spacing being reduced in the myocardium
• however, no alterations in actomyosin cross-bridge mass distribution are seen
|
• increase in size of cardiomyocytes
|
• increase in left ventricular end diastolic volume with higher left ventricular end systolic pressure, indicating higher heart contractility
|
growth/size/body
• heart-to-body weight ratio is increased
|
• decrease in number of nuclei indicating cardiac hypertrophy
• left ventricular volumes in diastole and systole are larger, indicating development of eccentric hypertrophy
|
cellular
• left ventricle exhibits signs of fibrosis
(J:178377)
• however, hearts exhibit normal size in 10-12 month old males
(J:178377)
• hearts exhibit severe fibrosis as early as 6 months of age
(J:202154)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hypertrophic cardiomyopathy 8 | DOID:0110314 |
OMIM:608751 |
J:202154 |