All Phenotypes Tg(Myh6-Tnni3*R146G)121Rbns MGI Mouse

cardiovascular system

abnormal myocardial fiber morphology ( J:243628 )

• some cardiomyocytes from parous females show features of hypoxia as evidenced by swollen mitochondria and large gaps between the sarcoplasmic reticulum, mitochondria, and sarcomeres

cardiac hypertrophy ( J:243628 )

• 13 month postpartum females exhibit cardiomyocyte hypertrophy

cardiac interstitial fibrosis ( J:243628 )

• 13 month postpartum females exhibit patchy areas of interstitial and perivascular fibrosis

increased cardiac muscle contractility ( J:243628 )

• heart contractility is enhanced

decreased cardiac muscle relaxation ( J:243628 )

• heart relaxation is impaired, with the time constant of relaxation prolonged

abnormal myocardial fiber physiology ( J:243628 )

• skinned papillary muscle from 6 week old mice show increased calcium sensitivity and depressed maximum tension

• however, no differences are seen in unloaded shortening velocity, maximum shortening velocity, or maximum relative power

increased response of heart to induced stress ( J:243628 )

• females stressed by pregnancy develop cardiac pathology

• however, males and nulliparous females exhibit no discernible heart pathology at any age

homeostasis/metabolism