mortality/aging
• mice die at 18-26 days after birth
|
• mice die at 18-26 days after birth
|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-Tnni3*R146G)121Rbns transgene insertion 121, Jeffrey Robbins MGI:5909328 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice die at 18-26 days after birth
|
• mice die at 18-26 days after birth
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• some cardiomyocytes from parous females show features of hypoxia as evidenced by swollen mitochondria and large gaps between the sarcoplasmic reticulum, mitochondria, and sarcomeres
|
|
• 13 month postpartum females exhibit cardiomyocyte hypertrophy
|
|
• 13 month postpartum females exhibit patchy areas of interstitial and perivascular fibrosis
|
• heart contractility is enhanced
|
• heart relaxation is impaired, with the time constant of relaxation prolonged
|
• skinned papillary muscle from 6 week old mice show increased calcium sensitivity and depressed maximum tension
• however, no differences are seen in unloaded shortening velocity, maximum shortening velocity, or maximum relative power
|
|
• females stressed by pregnancy develop cardiac pathology
• however, males and nulliparous females exhibit no discernible heart pathology at any age
|
|
• females stressed by pregnancy develop cardiac pathology
• however, males and nulliparous females exhibit no discernible heart pathology at any age
|
|
• some cardiomyocytes from parous females show features of hypoxia as evidenced by swollen mitochondria and large gaps between the sarcoplasmic reticulum, mitochondria, and sarcomeres
|
• heart contractility is enhanced
|
• heart relaxation is impaired, with the time constant of relaxation prolonged
|
|
• 13 month postpartum females exhibit cardiomyocyte hypertrophy
|
|
• 13 month postpartum females exhibit patchy areas of interstitial and perivascular fibrosis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hypertrophic cardiomyopathy 7 | DOID:0110313 |
OMIM:613690 |
J:243628 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|