Phenotypes associated with this allele

• Allele Symbol: Cdc42ep4^tm1.1Ksh
• Allele Name: targeted mutation 1.1, Makoto Kinoshita
• Allele ID: MGI:5910399
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc42ep4^tm1.1Ksh/Cdc42ep4^tm1.1Ksh	involves: C57BL/6 * C57BL/6N	MGI:5910400

Genotype
MGI:5910400

hm1

• Allelic Composition: Cdc42ep4^tm1.1Ksh/Cdc42ep4^tm1.1Ksh
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:228294 )

N • architecture of the cerebellum is similar to controls

N • evoked excitatory postsynaptic currents in granule cell layer climbing fibers is similar to controls indicating climbing fiber monoinnervation of Purkinje cells is established as in controls

abnormal synaptic transmission ( J:228294 )

• impaired glutamate clearance at parallel fiber - Purkinje cell synapses

abnormal excitatory postsynaptic currents ( J:228294 )

• reduced inhibition of parallel fiber EPSC amplitude by gamma-D-glutamylglycine suggesting that the size of glutamate transient at parallel fiber - Purkinje cell synapses was significantly higher

prolonged excitatory postsynaptic current decay time ( J:228294 )

• prolonged decay time suggesting a delay in glutamate clearance from parallel fiber - Purkinje cell synapses

enhanced AMPA-mediated synaptic currents ( J:228294 )

• large baseline inward current in Purkinje cells generated by AMPARs exposed to excessive glutamate

behavior/neurological

abnormal motor learning ( J:228294 )

• slope of the learning curve on a rotating rod is flatter at 12 weeks of age and lower at 24 weeks of age

abnormal locomotor coordination ( J:228294 )

• subpial injection with 100uM DL-threo-beta- benzyloxyaspartic acid with cyclothiazide results in transient motor incoordination in null mice but not controls