embryo
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
(J:279207)
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• embryos arrest prior to gastrulation
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• embryos are much smaller than controls at E7.5
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• a rudimentary egg cylinder is observed at E7.5
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• no head folds are present at E7.5
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• no embryonic node is present at E7.5
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• no morphological evidence of primitive streak formation is observed at E7.5
• no Brachyury (T)-positive cells are present at E7.5, indicating failure of primitive streak initiation
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growth/size/body
• embryos are much smaller than controls at E7.5
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mortality/aging
IMPC - JAX
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IMPC - JAX
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• homozygous embryos are recovered at E7.5 (19% versus expected 25%, n=27) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5
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