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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ndufa9em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5910587
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ndufa9em1(IMPC)J/Ndufa9em1(IMPC)J C57BL/6NJ-Ndufa9em1(IMPC)J/Mmjax MGI:6262985


Genotype
MGI:6262985
hm1
Allelic
Composition
Ndufa9em1(IMPC)J/Ndufa9em1(IMPC)J
Genetic
Background
C57BL/6NJ-Ndufa9em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufa9em1(IMPC)J mutation (2 available); any Ndufa9 mutation (22 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Ndufa9em1(IMPC)J/Ndufa9em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)
• embryos arrest prior to gastrulation
• embryos are much smaller than controls at E7.5
• a rudimentary egg cylinder is observed at E7.5
• no head folds are present at E7.5
• no embryonic node is present at E7.5
• no morphological evidence of primitive streak formation is observed at E7.5
• no Brachyury (T)-positive cells are present at E7.5, indicating failure of primitive streak initiation

growth/size/body
• embryos are much smaller than controls at E7.5

mortality/aging
• homozygous embryos are recovered at E7.5 (19% versus expected 25%, n=27) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory