Phenotypes associated with this allele

• Allele Symbol: Mcur1^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5910730
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mcur1^tm1c(KOMP)Wtsi/Mcur1^tm1c(KOMP)Wtsi A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:5912149
cn2	Mcur1^tm1c(KOMP)Wtsi/Mcur1^tm1c(KOMP)Wtsi Tg(Cdh5-cre)7Mlia/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:5912150

Genotype
MGI:5912149

cn1

• Allelic Composition: Mcur1^{tm1c(KOMP)Wtsi}/Mcur1^{tm1c(KOMP)Wtsi}; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0332_3_A12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:235756 )

• some mice die by 3 weeks of age

• however, some mice are viable

cellular

abnormal mitochondrial physiology ( J:235756 )

• cardiomyocyte mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells

• cardiomyocytes mitochondria exhibit defective inward mitochondrial calcium ion uniporter-dependent inward current compared with control cells

• however, mitochondrial membrane potential is normal

growth/size/body

decreased body size ( J:235756 )

Genotype
MGI:5912150

cn2

• Allelic Composition: Mcur1^{tm1c(KOMP)Wtsi}/Mcur1^{tm1c(KOMP)Wtsi}; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0332_3_A12

respiratory system

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

homeostasis/metabolism

increased basal metabolism ( J:235756 )

• increased resting heat production compared with controls

cellular

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

abnormal mitochondrial physiology ( J:235756 )

• endothelial cell and fibroblast mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells