Analysis Tools
mortality/aging
|
• due to selective rescue of Runx1 in hematopoietic cells, mice are able to survive up to E18.5, whereas single Runx1tm1Sata homozygotes die at ~E12.5
|
craniofacial
|
• at E17.5, all mice exhibit partial anterior clefting at the first rugae area and between the primary and the secondary palates
|
|
• SEM analysis of the palatal shelves at the first rugae site showed less obvious morphological changes associated with palatal fusion, unlike in wild-type controls where the fusing epithelial surface in the anterior palate shows a rounded cobblestone-like appearance
• TEM analysis of the palatal shelf edge showed a lack of surface cell desquamation and cell blebs prior to fusion and no signs of epithelial cell disintegration or fragmentation in their nuclei, unlike in wild-type controls
|
|
• in the first rugae region, the bilateral palatal shelves exhibit normal thickness and length and elongate to the midline with no signs of growth retardation but there is no contact in the midline, either between the palatal shelves or between the palatal shelves and the nasal septum
• however, the secondary palate is fused completely in middle and posterior regions and mesenchymal confluence is observed
|
|
• at E17.5, all mice exhibit partial anterior clefting at the first rugae area and between the primary and the secondary palates
• anterior clefting is likely due to a failure in epithelial fusion
|
|
• at E17.5, the secondary palate is fused completely in middle and posterior regions but fails to contact the inferior border of the nasal septum, indicating incomplete fusion between the secondary palate and the nasal septum
• however, the septal cartilage is of normal size
|
digestive/alimentary system
|
• at E17.5, all mice exhibit partial anterior clefting at the first rugae area and between the primary and the secondary palates
|
|
• SEM analysis of the palatal shelves at the first rugae site showed less obvious morphological changes associated with palatal fusion, unlike in wild-type controls where the fusing epithelial surface in the anterior palate shows a rounded cobblestone-like appearance
• TEM analysis of the palatal shelf edge showed a lack of surface cell desquamation and cell blebs prior to fusion and no signs of epithelial cell disintegration or fragmentation in their nuclei, unlike in wild-type controls
|
|
• in the first rugae region, the bilateral palatal shelves exhibit normal thickness and length and elongate to the midline with no signs of growth retardation but there is no contact in the midline, either between the palatal shelves or between the palatal shelves and the nasal septum
• however, the secondary palate is fused completely in middle and posterior regions and mesenchymal confluence is observed
|
|
• at E17.5, all mice exhibit partial anterior clefting at the first rugae area and between the primary and the secondary palates
• anterior clefting is likely due to a failure in epithelial fusion
|
growth/size/body
|
• at E17.5, all mice exhibit partial anterior clefting at the first rugae area and between the primary and the secondary palates
|
|
• SEM analysis of the palatal shelves at the first rugae site showed less obvious morphological changes associated with palatal fusion, unlike in wild-type controls where the fusing epithelial surface in the anterior palate shows a rounded cobblestone-like appearance
• TEM analysis of the palatal shelf edge showed a lack of surface cell desquamation and cell blebs prior to fusion and no signs of epithelial cell disintegration or fragmentation in their nuclei, unlike in wild-type controls
|
|
• in the first rugae region, the bilateral palatal shelves exhibit normal thickness and length and elongate to the midline with no signs of growth retardation but there is no contact in the midline, either between the palatal shelves or between the palatal shelves and the nasal septum
• however, the secondary palate is fused completely in middle and posterior regions and mesenchymal confluence is observed
|
|
• at E17.5, all mice exhibit partial anterior clefting at the first rugae area and between the primary and the secondary palates
• anterior clefting is likely due to a failure in epithelial fusion
|
|
• at E17.5, the secondary palate is fused completely in middle and posterior regions but fails to contact the inferior border of the nasal septum, indicating incomplete fusion between the secondary palate and the nasal septum
• however, the septal cartilage is of normal size
|
respiratory system
|
• at E17.5, the secondary palate is fused completely in middle and posterior regions but fails to contact the inferior border of the nasal septum, indicating incomplete fusion between the secondary palate and the nasal septum
• however, the septal cartilage is of normal size
|
