All Phenotypes Rnaseh2b<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rnaseh2b^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5911393

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL	MGI:5911410
cn2	Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi} Tg(Pgk1-cre)1Lni/0	involves: BALB/c * C57BL/6 * C57BL/6N * SJL	MGI:5911413

Allelic Composition	Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL
Cell Lines	EPD0087_4_A02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Rnaseh2b^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Rnaseh2b mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:186986 )

N	• mice exhibit normal numbers of B cells in the spleen

decreased B cell proliferation ( J:186986 )

• LPS-induced

hematopoietic system

decreased B cell proliferation ( J:186986 )

• LPS-induced

cellular

decreased B cell proliferation ( J:186986 )

• LPS-induced

Allelic Composition	Rnaseh2b^{tm1c(EUCOMM)Wtsi}/Rnaseh2b^{tm1c(EUCOMM)Wtsi} Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: BALB/c * C57BL/6 * C57BL/6N * SJL
Cell Lines	EPD0087_4_A02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2b^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Rnaseh2b mutation (43 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:186986 )

• mice exhibit embryonic lethality similar to Rnaseh2c^tm1Roer homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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