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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet1tm1.2Jae
targeted mutation 1.2, Rudolf Jaenisch
MGI:5911447
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0 		involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB MGI:7439998
cn2
 		Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2+
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0 		involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB MGI:7439999


Genotype
MGI:7439998
cn1
Allelic
Composition		 Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.2Jae mutation (0 available); any Tet1 mutation (143 available)
Tet2tm1.1Iaai mutation (2 available); any Tet2 mutation (779 available)
Tet3tm1.1Yzhg mutation (0 available); any Tet3 mutation (60 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged spleen ( J:333574 )
• splenomegaly at age 5 weeks

hematopoietic system
enlarged spleen ( J:333574 )
• splenomegaly at age 5 weeks

immune system
enlarged spleen ( J:333574 )
• splenomegaly at age 5 weeks
enlarged lymph nodes ( J:333574 )
• lymphadenopathy at age 5 weeks




Genotype
MGI:7439999
cn2
Allelic
Composition		 Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2+
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.2Jae mutation (0 available); any Tet1 mutation (143 available)
Tet2tm1.1Iaai mutation (2 available); any Tet2 mutation (779 available)
Tet3tm1.1Yzhg mutation (0 available); any Tet3 mutation (60 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased effector memory T-helper cell number ( J:333574 )
• greatly reduced CD4 expression upon T cell proliferation

immune system
immune system phenotype ( J:333574 )
N
• no autoimmune phenotypes
• normal spleen and lymph node size
• normal proportions of naive CD44- CD62L+ T lymphocyte compartments
decreased effector memory T-helper cell number ( J:333574 )
• greatly reduced CD4 expression upon T cell proliferation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory