About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai
targeted mutation 3, Iannis Aifantis
MGI:5911566
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 MGI:5911578
cx2
 		Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 MGI:5911579


Genotype
MGI:5911578
cx1
Allelic
Composition		 Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:229031 )
• lineage skewing is seen following prolonged doxycycline exposure (30 days)
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+)
increased myeloid cell number ( J:229031 )
• increase in the proportion of myelomonocytic (Cd11b+/Gr1+) and erythroid (CD71+/Ter119+) cells
abnormal hematopoietic stem cell morphology ( J:229031 )
• increase in nuclear size in sorted Lineage-/c-Kit+ progenitor cells not associated with an increase of genomic material or instability
decreased hematopoietic stem cell number ( J:229031 )
• decrease in the number of GFP+ cells in the long-term (CD150+) and short-term (CD150-/CD48-) subsets

immune system
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+)




Genotype
MGI:5911579
cx2
Allelic
Composition		 Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai mutation (0 available); any Col1a1 mutation (161 available)
Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai mutation (0 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:229031 )
• lineage skewing is seen following short term doxycycline exposure
myeloid hyperplasia ( J:229031 )
• develops over time
anemia ( J:229031 )
• develops over time
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+) develops over time
abnormal spleen morphology ( J:229031 )
• disrupted morphology
enlarged spleen ( J:229031 )
• following short term doxycycline exposure

immune system
myeloid hyperplasia ( J:229031 )
• develops over time
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+) develops over time
abnormal spleen morphology ( J:229031 )
• disrupted morphology
enlarged spleen ( J:229031 )
• following short term doxycycline exposure

growth/size/body
enlarged spleen ( J:229031 )
• following short term doxycycline exposure




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory