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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai
targeted mutation 3, Iannis Aifantis
MGI:5911566
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 MGI:5911578
cx2
 		Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C57BL/6 MGI:5911579


Genotype
MGI:5911578
cx1
Allelic
Composition		 Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:229031 )
• lineage skewing is seen following prolonged doxycycline exposure (30 days)
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+)
increased myeloid cell number ( J:229031 )
• increase in the proportion of myelomonocytic (Cd11b+/Gr1+) and erythroid (CD71+/Ter119+) cells
abnormal hematopoietic stem cell morphology ( J:229031 )
• increase in nuclear size in sorted Lineage-/c-Kit+ progenitor cells not associated with an increase of genomic material or instability
decreased hematopoietic stem cell number ( J:229031 )
• decrease in the number of GFP+ cells in the long-term (CD150+) and short-term (CD150-/CD48-) subsets

immune system
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+)




Genotype
MGI:5911579
cx2
Allelic
Composition		 Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai mutation (0 available); any Col1a1 mutation (163 available)
Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:229031 )
• lineage skewing is seen following short term doxycycline exposure
myeloid hyperplasia ( J:229031 )
• develops over time
anemia ( J:229031 )
• develops over time
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+) develops over time
abnormal spleen morphology ( J:229031 )
• disrupted morphology
enlarged spleen ( J:229031 )
• following short term doxycycline exposure

immune system
myeloid hyperplasia ( J:229031 )
• develops over time
decreased B cell number ( J:229031 )
• decrease in the proportion of B cell population (B220+) develops over time
abnormal spleen morphology ( J:229031 )
• disrupted morphology
enlarged spleen ( J:229031 )
• following short term doxycycline exposure

growth/size/body
enlarged spleen ( J:229031 )
• following short term doxycycline exposure




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory