Phenotypes associated with this allele

• Allele Symbol: Prim1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5911622
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prim1^em1(IMPC)J/Prim1^em1(IMPC)J	C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax	MGI:6377658
hm2	Prim1^em1(IMPC)J/Prim1^em1(IMPC)J	C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax	MGI:6394364
ht3	Prim1^em1(IMPC)J/Prim1^+	C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax	MGI:6263229

Genotype
MGI:6377658

hm1

• Allelic Composition: Prim1^em1(IMPC)J/Prim1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• normal looking blastocysts are present at lower than expected Mendelian ratios at E3.5 (11% versus 25%); some excess resorption sites but no embryos are observed at E7.5

embryo

absent primitive endoderm ( J:279207 )

• limited or no primitive endoderm (PrE) cells are observed after 3 days in culture

absent trophectoderm ( J:279207 )

• although blastocysts hatch from the zona pellucida and form outgrowths with apparent inner cell mass, limited or no trophectoderm (TE) is observed after 3 days in culture

Genotype
MGI:6394364

hm2

• Allelic Composition: Prim1^em1(IMPC)J/Prim1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Prim1

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6263229

ht3

• Allelic Composition: Prim1^em1(IMPC)J/Prim1⁺
• Genetic Background: C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Prim1

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - JAX