Phenotypes associated with this allele

• Allele Symbol: Prim1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5911622
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prim1^em1(IMPC)J/Prim1^em1(IMPC)J	C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax	MGI:6394364
ht2	Prim1^em1(IMPC)J/Prim1^+	C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax	MGI:6263229

Genotype
MGI:6394364

hm1

• Allelic Composition: Prim1^em1(IMPC)J/Prim1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Prim1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Prim1^em1(IMPC)J/ Prim1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form outgrowths with apparent inner cell mass but limited/no trophectoderm or primitive endoderm cells.

embryo

absent primitive endoderm ( J:279207 )

• limited or no primitive endoderm (PrE) cells are observed after 3 days in culture

absent trophectoderm ( J:279207 )

• although blastocysts hatch from the zona pellucida and form outgrowths with apparent inner cell mass, limited or no trophectoderm (TE) is observed after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• normal looking blastocysts are present at E3.5 (11% versus expected 25%, n=27); some excess resorption sites but no homozygous embryos are observed at E7.5

Genotype
MGI:6263229

ht2

• Allelic Composition: Prim1^em1(IMPC)J/Prim1⁺
• Genetic Background: C57BL/6NJ-Prim1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Prim1

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - JAX