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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tifabtm1.1Dsta
targeted mutation 1.1, Daniel T Starczynowski
MGI:5911664
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tifabtm1.1Dsta/Tifabtm1.1Dsta involves: 129 * C57BL/6 * C57BL/6J MGI:5911665
ht2
 		Tifabtm1.1Dsta/Tifab+ involves: 129 * C57BL/6 * C57BL/6J MGI:5911666
cx3
 		Mir146tm1.1Bal/Mir146tm1.1Bal
Tifabtm1.1Dsta/Tifabtm1.1Dsta 		involves: 129 * C57BL/6 * C57BL/6J MGI:5911667


Genotype
MGI:5911665
hm1
Allelic
Composition		 Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tifabtm1.1Dsta mutation (0 available); any Tifab mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:229024 )
• a small subset of mice over 1 year of age become moribund

hematopoietic system
decreased hematopoietic stem cell proliferation ( J:229024 )
• bone marrow cells show significant disadvantage in competitive transplantation and/or homing
enlarged spleen ( J:229024 )
• seen in a small subset of mice over 1 year of age
abnormal neutrophil morphology ( J:229024 )
• dysplastic hypersegmented neutrophils following bone marrow transplantation to lethally radiate syngenic recipient mice
decreased hematopoietic cell number ( J:229024 )
• a small subset of mice over 1 year of age display cytopenia
decreased leukocyte cell number ( J:229024 )
• progressive decline in white blood cell counts without changes in red blood cell or platelet counts when bone marrow is transferred to lethally radiate syngenic recipient mice
• however, no differences in white blood cell counts are seen at 6 or 12 months of age in homozygous mice
decreased neutrophil cell number ( J:229024 )
• decrease in neutrophil numbers at 6 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
decreased lymphocyte cell number ( J:229024 )
• decrease in lymphocyte numbers at 6 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
decreased monocyte cell number ( J:229024 )
• decrease in monocyte numbers at 6 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
abnormal hematopoietic stem cell morphology ( J:229024 )
• LSK cells form ~50% more CFU-G colonies

immune system
enlarged spleen ( J:229024 )
• seen in a small subset of mice over 1 year of age
abnormal neutrophil morphology ( J:229024 )
• dysplastic hypersegmented neutrophils following bone marrow transplantation to lethally radiate syngenic recipient mice
decreased neutrophil cell number ( J:229024 )
• decrease in neutrophil numbers at 6 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
decreased leukocyte cell number ( J:229024 )
• progressive decline in white blood cell counts without changes in red blood cell or platelet counts when bone marrow is transferred to lethally radiate syngenic recipient mice
• however, no differences in white blood cell counts are seen at 6 or 12 months of age in homozygous mice
decreased lymphocyte cell number ( J:229024 )
• decrease in lymphocyte numbers at 6 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
decreased monocyte cell number ( J:229024 )
• decrease in monocyte numbers at 6 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice

cellular
decreased hematopoietic stem cell proliferation ( J:229024 )
• bone marrow cells show significant disadvantage in competitive transplantation and/or homing

growth/size/body
enlarged spleen ( J:229024 )
• seen in a small subset of mice over 1 year of age




Genotype
MGI:5911666
ht2
Allelic
Composition		 Tifabtm1.1Dsta/Tifab+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tifabtm1.1Dsta mutation (0 available); any Tifab mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:229024 )
• a small subset of mice over 1 year of age become moribund

hematopoietic system
decreased hematopoietic stem cell proliferation ( J:229024 )
• bone marrow cells show significant disadvantage in competitive transplantation and/or homing
enlarged spleen ( J:229024 )
• seen in a small subset of mice over 1 year of age
decreased hematopoietic cell number ( J:229024 )
• a small subset of mice over 1 year of age display cytopenia
abnormal hematopoietic stem cell morphology ( J:229024 )
• LSK cells form ~50% more CFU-G colonies

immune system
enlarged spleen ( J:229024 )
• seen in a small subset of mice over 1 year of age

cellular
decreased hematopoietic stem cell proliferation ( J:229024 )
• bone marrow cells show significant disadvantage in competitive transplantation and/or homing

growth/size/body
enlarged spleen ( J:229024 )
• seen in a small subset of mice over 1 year of age




Genotype
MGI:5911667
cx3
Allelic
Composition		 Mir146tm1.1Bal/Mir146tm1.1Bal
Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146tm1.1Bal mutation (2 available); any Mir146 mutation (9 available)
Tifabtm1.1Dsta mutation (0 available); any Tifab mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased neutrophil cell number ( J:229024 )
• decrease in neutrophil numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
• decrease is greater than in either single homozygote
decreased lymphocyte cell number ( J:229024 )
• decrease in lymphocyte numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
• decrease is greater than in either single homozygote
abnormal hematopoietic stem cell morphology ( J:229024 )
• total colony formation is increased in vitro and progenitors show an additive increase in CFU-G colony formation compared to either single homozygote

immune system
decreased neutrophil cell number ( J:229024 )
• decrease in neutrophil numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
• decrease is greater than in either single homozygote
decreased lymphocyte cell number ( J:229024 )
• decrease in lymphocyte numbers at 4 months post transplantation when bone marrow is transferred to lethally radiate syngenic recipient mice
• decrease is greater than in either single homozygote




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory