All Phenotypes Nus1<tm1.1Qrm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nus1^tm1.1Qrm
targeted mutation 1.1, Qing Robert Miao
MGI:5911854

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6 * DBA * SJL	MGI:6106900
cn2	Nr1h3^tm1Djm/Nr1h3^tm1Djm Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6 * DBA * SJL	MGI:6106901
cn3	Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} Nus1^tm1.1Qrm/Nus1^tm1.1Qrm	involves: 129 * C57BL/6 * SJL	MGI:6106902
cn4	Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6361030
cn5	Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Tg(Tek-cre)1Ywa/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:6361029

Allelic Composition	Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129 * C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.1Qrm mutation (0 available); any Nus1 mutation (19 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:243753 )

• induction of hepatic lipogenesis when fed Western diet

abnormal circulating cholesterol level ( J:243753 )

• both total and free when fed Western diet

increased circulating free fatty acids level ( J:243753 )

• when fed Western diet

increased circulating triglyceride level ( J:243753 )

• when fed Western diet

decreased liver cholesterol level ( J:243753 )

• both total and free when fed Western diet

increased liver free fatty acids level ( J:243753 )

• when fed Western diet

increased liver triglyceride level ( J:243753 )

• when fed Western diet

liver/biliary system

decreased liver cholesterol level ( J:243753 )

• both total and free when fed Western diet

increased liver free fatty acids level ( J:243753 )

• when fed Western diet

increased liver triglyceride level ( J:243753 )

• when fed Western diet

Allelic Composition	Nr1h3^tm1Djm/Nr1h3^tm1Djm Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129 * C57BL/6 * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h3^tm1Djm mutation (3 available); any Nr1h3 mutation (32 available)
Nus1^tm1.1Qrm mutation (0 available); any Nus1 mutation (19 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:243753 )

N	• when fed Western diet • circulating triglyceride level • liver triglyceride level • circulating free fatty acid level • liver free fatty acid level • circulating cholesterol level both total and free

increased liver cholesterol level ( J:243753 )

• both total and free when fed Western diet

liver/biliary system

increased liver cholesterol level ( J:243753 )

• both total and free when fed Western diet

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} Nus1^tm1.1Qrm/Nus1^tm1.1Qrm
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Nus1^tm1.1Qrm mutation (0 available); any Nus1 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:243753 )

• induction of hepatic lipogenesis when fed Western diet

increased liver free fatty acids level ( J:243753 )

• when fed Western diet

increased liver triglyceride level ( J:243753 )

• when fed Western diet

liver/biliary system

increased liver free fatty acids level ( J:243753 )

• when fed Western diet

increased liver triglyceride level ( J:243753 )

• when fed Western diet

hepatic steatosis ( J:243753 )

• when fed Western diet

Allelic Composition	Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.1Qrm mutation (0 available); any Nus1 mutation (19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal brain vasculature morphology ( J:229464 )

• E10.5 embryos from tamoxifen-treated mothers exhibit aberrant cerebral blood vessel pattering

abnormal vascular development ( J:229464 )

• E10.5 embryos from tamoxifen-treated mothers have dilated and disrupted organization of blood vessels

embryo

decreased embryo size ( J:229464 )

• E01.5 embryos are smaller in size when pregnant females are treated with tamoxifen at E8.5

growth/size/body

decreased embryo size ( J:229464 )

• E01.5 embryos are smaller in size when pregnant females are treated with tamoxifen at E8.5

nervous system

abnormal brain vasculature morphology ( J:229464 )

• E10.5 embryos from tamoxifen-treated mothers exhibit aberrant cerebral blood vessel pattering

Allelic Composition	Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1^tm1.1Qrm mutation (0 available); any Nus1 mutation (19 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:229464 )

• embryonic lethality at E10.5-E11.5

growth/size/body

decreased embryo size ( J:229464 )

embryo

abnormal vitelline vasculature morphology ( J:229464 )

• E10, but not E9, yolk sac shows aberrant blood vessel development

decreased embryo size ( J:229464 )

cardiovascular system

abnormal brain vasculature morphology ( J:229464 )

• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern

• cerebral blood vessels are highly dilated, being normal at E8.5 but becoming dilated by E9.5

abnormal vascular development ( J:229464 )

• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern

• the communicating artery is lost and disruption of major artery patterning is seen

• E10, but not E9, yolk sac shows aberrant blood vessel development

• however, no defect in cardiac development is seen and no obvious bronchial arch artery defects are seen

abnormal vitelline vasculature morphology ( J:229464 )

• E10, but not E9, yolk sac shows aberrant blood vessel development

nervous system

abnormal brain vasculature morphology ( J:229464 )

• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern

• cerebral blood vessels are highly dilated, being normal at E8.5 but becoming dilated by E9.5

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