Phenotypes associated with this allele

• Allele Symbol: Tg(Tyr-cre)#Lru
• Allele Name: transgene insertion, Lionel Larue
• Allele ID: MGI:5911868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Tyr-cre)#Lru/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:6267333

Genotype
MGI:6267333

cn1

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Tg(Tyr-cre)#Lru/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

The number of melanocyte lineage cells is dramatically reduced in Rbpj^tm1Hon Rbpj^tm1Hon Tg(Tyr-cre)#Lru/0 mice

pigmentation

abnormal hair follicle melanocyte morphology ( J:111228 )

• mice show a severe reduction of melanocytes (MCs) in hair follicles (HFs) at P4 and virtual loss of MCs in HFs at P32

• a reduction of MCs is noted in the hair matrix (HM) at P4; however, mature MCs are still retained in the HM at P12

• by P32, HFs lack both immature melanoblasts in the lower permanent portion (LPP) and differentiated MCs in the HM, indicating loss of the MSCs

abnormal hair follicle melanogenesis ( J:111228 )

• initial wave of melanogenesis during HF morphogenesis is severely impaired

absent coat pigmentation ( J:111228 )

• mice exhibit loss of hair pigmentation after the first hair molting

diluted coat color ( J:111228 )

• at P4 and P18, mice exhibit severe coat-color dilution in the initial hairs

• at P18, hairs are a mixture of pigmented and unpigmented, whereas hairs from control mice are fully pigmented

• by P32 (subsequent hair cycle), almost all hairs grown in a shaved area are unpigmented

decreased melanocyte number ( J:111228 )

• mice show a severe reduction of melanocytes (MCs) in hair follicles (HFs) at P4 and virtual loss of MCs in HFs at P32

• a reduction of MCs is noted in the hair matrix (HM) at P4; however, mature MCs are still retained in the HM at P12

• by P32, HFs lack both immature melanoblasts in the lower permanent portion (LPP) and differentiated MCs in the HM, indicating loss of the MSCs

integument

abnormal hair follicle melanocyte morphology ( J:111228 )

• mice show a severe reduction of melanocytes (MCs) in hair follicles (HFs) at P4 and virtual loss of MCs in HFs at P32

• a reduction of MCs is noted in the hair matrix (HM) at P4; however, mature MCs are still retained in the HM at P12

• by P32, HFs lack both immature melanoblasts in the lower permanent portion (LPP) and differentiated MCs in the HM, indicating loss of the MSCs

abnormal hair follicle melanogenesis ( J:111228 )

• initial wave of melanogenesis during HF morphogenesis is severely impaired

absent coat pigmentation ( J:111228 )

• mice exhibit loss of hair pigmentation after the first hair molting

diluted coat color ( J:111228 )

• at P4 and P18, mice exhibit severe coat-color dilution in the initial hairs

• at P18, hairs are a mixture of pigmented and unpigmented, whereas hairs from control mice are fully pigmented

• by P32 (subsequent hair cycle), almost all hairs grown in a shaved area are unpigmented

embryo

abnormal melanoblast morphology ( J:111228 )

• whole-mount staining of dorsal skin epidermis using anti-c-Kit antibody revealed a significant reduction of melanoblast numbers at E16.5 and P0 relative to control mice

• at P4, some Dct+ melanoblasts are still detected in the lower permanent portion (LPP) of HFs; however, unlike in control mice, these are essentially lost by P12, indicating loss of melanocyte stem cells (MSCs)

nervous system

abnormal melanoblast morphology ( J:111228 )

• whole-mount staining of dorsal skin epidermis using anti-c-Kit antibody revealed a significant reduction of melanoblast numbers at E16.5 and P0 relative to control mice

• at P4, some Dct+ melanoblasts are still detected in the lower permanent portion (LPP) of HFs; however, unlike in control mice, these are essentially lost by P12, indicating loss of melanocyte stem cells (MSCs)