Analysis Tools
cardiovascular system
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• mice show a trend towards increased cardiomyocyte diameter with an increase in the variability of cardiomyocyte size
• delta-sarcoglycan is sequestered into the nucleus instead of the plasma membrane along with partial nuclear sequestration of beta- and gamma-sarcoglycan, and mislocalization of lamin A/C and emerin throughout the nucleoplasm
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• heart to body weight ratios of 12 week old mice is increased
|
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• mice show dilated cardiomyopathy at a young age
• however, focal fibrosis is hearts is not seen and the sarcolemmal membrane is intact
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muscle
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• mice show a trend towards increased cardiomyocyte diameter with an increase in the variability of cardiomyocyte size
• delta-sarcoglycan is sequestered into the nucleus instead of the plasma membrane along with partial nuclear sequestration of beta- and gamma-sarcoglycan, and mislocalization of lamin A/C and emerin throughout the nucleoplasm
|
|
• mice show dilated cardiomyopathy at a young age
• however, focal fibrosis is hearts is not seen and the sarcolemmal membrane is intact
|
growth/size/body
|
• heart to body weight ratios of 12 week old mice is increased
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy 1L | DOID:0110436 |
OMIM:606685 |
J:117855 | |
