Phenotypes associated with this allele

• Allele Symbol: Riok1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5911955
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Riok1^em1(IMPC)J/Riok1^em1(IMPC)J	C57BL/6NJ-Riok1^em1(IMPC)J/Mmjax	MGI:6394371

Genotype
MGI:6394371

hm1

• Allelic Composition: Riok1^em1(IMPC)J/Riok1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Riok1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Riok1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Riok1^em1(IMPC)J/Riok1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form normal outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although normal looking blastocysts are present at E3.5 (19% versus expected 25%, n=32), no embryos or excess resorption sites are observed at E7.5

• in vitro, blastocysts hatch from the zona pellucida and form normal outgrowth colonies with apparent inner cell mass (ICM), trophectoderm (TE), and primitive endoderm (PrE) cells after 3 days in culture