All Phenotypes Smarcd1<tm1.1Jddl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apoe^tm1Unc/Apoe^tm1Unc Smarcd1^tm1.1Jddl/Smarcd1^tm1.1Jddl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5912277
cn2	Smarcd1^tm1.1Jddl/Smarcd1^tm1.1Jddl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA	MGI:5912276

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Smarcd1^tm1.1Jddl/Smarcd1^tm1.1Jddl Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Smarcd1^tm1.1Jddl mutation (1 available); any Smarcd1 mutation (30 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:228944 )

• area of atherosclerotic lesions is reduced by about 53% compared to mice homozygous null for Apoe alone

homeostasis/metabolism

decreased circulating cholesterol level ( J:228944 )

• cholesterol levels are approximately 30% lower in Western diet fed mice compared to diet matched controls

abnormal bile salt homeostasis ( J:228944 )

• expression analysis indicates bile acid metabolism is reduced

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased intestinal cholesterol absorption ( J:228944 )

decreased circulating cholesterol level ( J:228944 )

• partially resistant to Western diet-induced hypercholesterolemia despite similar weight gain compared to controls

• total plasma cholesterol concentration on a Western diet is approximately 40% lower compared to controls

• however, levels in mice on a standard chow diet are similar to controls

decreased circulating HDL cholesterol level ( J:228944 )

• in mice on a Western diet

decreased circulating LDL cholesterol level ( J:228944 )

• in mice on a Western diet

decreased circulating VLDL cholesterol level ( J:228944 )

• in mice on a Western diet

decreased circulating alanine transaminase level ( J:228944 )

decreased circulating aspartate transaminase level ( J:228944 )

decreased bile salt level ( J:228944 )

• 37% decrease in total bile volume and biliary acid content

• the liver/gallbladder and intestine bile acid pool sizes are both significantly decreased

increased cholesterol level ( J:228944 )

• cholesterol excretion in feces is significantly increased

increased feces cholesterol level ( J:228944 )

• cholesterol excretion in feces is significantly increased

increased liver cholesterol level ( J:228944 )

digestive/alimentary system

increased feces cholesterol level ( J:228944 )

• cholesterol excretion in feces is significantly increased

decreased intestinal cholesterol absorption ( J:228944 )

liver/biliary system

increased liver cholesterol level ( J:228944 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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