Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-ERBB2*)26Kkw
• Allele Name: transgene insertion 26, Kwok-Kin Wong
• Allele ID: MGI:5912483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-ERBB2*)26Kkw/0	involves: FVB/N	MGI:5912488

Genotype
MGI:5912488

cx1

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-ERBB2*)26Kkw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:143874 )

• caused by asphyxiation due to intrabronchial carcinoma in doxycycline-treated mice

• all doxycycline-treated mice die by around 10 weeks

neoplasm

increased lung tumor incidence ( J:143874 )

• in doxycycline-treated mice after 1 week with increasing tumor volume over an 8 week period

• tumors in doxycycline-treated mice develop from bronchiolar epithelium

• however, withdrawal of doxycycline leads to tumor regression

increased lung carcinoma incidence ( J:143874 )

• intrabronchal carcinomas after 3 to 4 weeks leading to asphyxiation in doxycycline-treated mice

increased lung non-small cell carcinoma incidence ( J:143874 )

• doxycycline-treated mice develop adenosquamous carcinomas

respiratory system

increased lung tumor incidence ( J:143874 )

• in doxycycline-treated mice after 1 week with increasing tumor volume over an 8 week period

• tumors in doxycycline-treated mice develop from bronchiolar epithelium

• however, withdrawal of doxycycline leads to tumor regression

increased lung carcinoma incidence ( J:143874 )

• intrabronchal carcinomas after 3 to 4 weeks leading to asphyxiation in doxycycline-treated mice

increased lung non-small cell carcinoma incidence ( J:143874 )

• doxycycline-treated mice develop adenosquamous carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adenosquamous lung carcinoma		DOID:4829		J:143874