Phenotypes associated with this allele

• Allele Symbol: Capzb^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5925338
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Capzb^tm1c(EUCOMM)Wtsi/Capzb^tm1c(EUCOMM)Wtsi Gt(ROSA)26Sor^tm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor^+ Tg(Atoh1-cre)1Bfri/0	involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL	MGI:6098730
cn2	Capzb^tm1c(EUCOMM)Wtsi/Capzb^tm1c(EUCOMM)Wtsi Tg(Atoh1-cre)1Bfri/0	involves: C57BL/6N * CBA * SJL	MGI:6098728

Genotype
MGI:6098730

cn1

• Allelic Composition: Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi}; Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL
• Cell Lines: EPD0105_5_A09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal cochlea morphology ( J:246055 )

• increased actin aggregation in the adherens-junction region and expansion of the apical surface

decreased cochlear hair cell stereocilia number ( J:246055 )

• no distinguishable stereocilia

cochlear hair cell degeneration ( J:246055 )

• reduction in stereocilia diameter and length eventually followed by disappearance

abnormal cuticular plate morphology ( J:246055 )

• ruptures

abnormal vestibular hair cell stereociliary bundle morphology ( J:246055 )

• disrupted hair cell in some bundles

short vestibular hair cell stereocilia ( J:246055 )

• with decreased width

nervous system

decreased cochlear hair cell stereocilia number ( J:246055 )

• no distinguishable stereocilia

cochlear hair cell degeneration ( J:246055 )

• reduction in stereocilia diameter and length eventually followed by disappearance

abnormal vestibular hair cell stereociliary bundle morphology ( J:246055 )

• disrupted hair cell in some bundles

short vestibular hair cell stereocilia ( J:246055 )

• with decreased width

Genotype
MGI:6098728

cn2

• Allelic Composition: Capzb^{tm1c(EUCOMM)Wtsi}/Capzb^{tm1c(EUCOMM)Wtsi}; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: C57BL/6N * CBA * SJL
• Cell Lines: EPD0105_5_A09

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:246055 )

absent distortion product otoacoustic emissions ( J:246055 )

abnormal vestibular system physiology ( J:246055 )

• strongly reduced vestibular function

absent linear vestibular evoked potential ( J:246055 )

• undetectable in 4 of 5 mice

behavior/neurological

head shaking ( J:246055 )

• progressively worse after weaning

• however, mice do not exhibit circling