Phenotypes associated with this allele

• Allele Symbol: Ddrgk1^em1Brle
• Allele Name: endonuclease-mediated mutation 1, Brendan Lee
• Allele ID: MGI:5925352
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddrgk1^em1Brle/Ddrgk1^em1Brle	C57BL/6J-Ddrgk1^em1Brle	MGI:5925363

Genotype
MGI:5925363

hm1

• Allelic Composition: Ddrgk1^em1Brle/Ddrgk1^em1Brle
• Genetic Background: C57BL/6J-Ddrgk1^em1Brle

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:243374 )

• embryonic lethality between E11.5 and E12.5

embryo

abnormal limb bud morphology ( J:243374 )

• a trend towards significant increase in apoptosis and cell death in E11.5 limb buds

abnormal limb mesenchyme morphology ( J:243374 )

• condensation of mesenchymal cells does not occur in limb buds up to E12.5 indicating delayed chondrogenic mesenchymal condensation in the limb buds

• however, proper patterning of digit formation in limb buds occurs at E11.5 and E12.5

hematopoietic system

decreased erythrocyte cell number ( J:243374 )

• decrease in number of erythrocytes and their progenitor cells in peripheral blood

limbs/digits/tail

abnormal limb bud morphology ( J:243374 )

• a trend towards significant increase in apoptosis and cell death in E11.5 limb buds

abnormal limb mesenchyme morphology ( J:243374 )

• condensation of mesenchymal cells does not occur in limb buds up to E12.5 indicating delayed chondrogenic mesenchymal condensation in the limb buds

• however, proper patterning of digit formation in limb buds occurs at E11.5 and E12.5

skeleton

abnormal cartilage development ( J:243374 )

• in ex vivo chondrogenic differentiation assay, E11.5 mesenchymal cells generated fewer cartilaginous nodules than wild-type cells after 7 days in culture