All Phenotypes Gas2l3<tm1c(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gas2l3^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5925364

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6116291
cn2	Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu} Nkx2-5^tm2(cre)Rph/Nkx2-5⁺	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N	MGI:6116294

Allelic Composition	Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas2l3^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Gas2l3 mutation (72 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:244087 )

N	• no increase in heart weight, no dilation, and no fibrosis when tamoxifen is used to induce loss of expression in neonatal mice unlike when expression is absent in embryonic stages

abnormal fetal cardiomyocyte morphology ( J:244087 )

• in cultured cardiomyocytes after tamoxifen induction 22% become binucleated while very few cells were binucleate before tamoxifen exposure

abnormal fetal cardiomyocyte proliferation ( J:244087 )

• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission

cellular

abnormal fetal cardiomyocyte proliferation ( J:244087 )

• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission

abnormal mitotic cytokinesis ( J:244087 )

• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission

muscle

abnormal fetal cardiomyocyte proliferation ( J:244087 )

• increase in the proportion of cardiomyocytes with unresolved cytokinetic midbody structures indicating failed abscission

Allelic Composition	Gas2l3^{tm1c(EUCOMM)Hmgu}/Gas2l3^{tm1c(EUCOMM)Hmgu} Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas2l3^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Gas2l3 mutation (72 available)
Nkx2-5^tm2(cre)Rph mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:244087 )

• increase in heart to body weight ratio

cardiac interstitial fibrosis ( J:244087 )

dilated heart ( J:244087 )

dilated cardiomyopathy ( J:244087 )

muscle

dilated cardiomyopathy ( J:244087 )

growth/size/body

increased heart weight ( J:244087 )

• increase in heart to body weight ratio

cellular

cardiac interstitial fibrosis ( J:244087 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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