Phenotypes associated with this allele

• Allele Symbol: Clstn2^tm1Amcr
• Allele Name: targeted mutation 1, Ann Marie Craig
• Allele ID: MGI:6093445
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clstn2^tm1Amcr/Clstn2^tm1Amcr	B6.129P2-Clstn2^tm1Amcr	MGI:6093460

Genotype
MGI:6093460

hm1

• Allelic Composition: Clstn2^tm1Amcr/Clstn2^tm1Amcr
• Genetic Background: B6.129P2-Clstn2^tm1Amcr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:248293 )

• took longer time to find hidden platform during Morris water maze test collectively over the training period

• exhibited larger number of nose pokes into goal box before entering during Barnes maze test

• exhibited longer latency to enter goal box and longer total distance traveled during Barnes maze test

abnormal spatial reference memory ( J:248293 )

• spent significantly less time in target quadrant during Morris water maze test

• spent lower percentage of time in target quadrant during Barnes maze test

• made smaller percentage of correct nose pokes into goal box during Barnes maze test

• exhibited larger distance to target during Barnes maze test

increased locomotor activity ( J:248293 )

• in open field test

nervous system

abnormal inhibitory synapse morphology ( J:248293 )

• reduced GABAergic synapse density in hippocampus of adult mice as determined by immunofluorescence (CA1 and CA3 regions) and patch voltage-clamp experiments (CA1 pyramidal neurons)

• 26-40% reduced density of parvalbumin-positive terminals in CA1 and CA3 stratum pyramidale

• 25-56% reduced density of parvalbumin-positive neurons in hippocampal CA1, CA3, dentate gyrus, and